[4-(2-Chloroethoxy)phenyl]-naphthalen-1-ylmethanone | 888070-68-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(2-Chloroethoxy)phenyl]-naphthalen-1-ylmethanone
• CAS: 888070-68-6
• 化学式: C₁₉H₁₅ClO₂
• 分子量: 310.78
• InChiKey: KXOTZQCYLLTLGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  哌啶 、 [4-(2-Chloroethoxy)phenyl]-naphthalen-1-ylmethanone 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 6.0h， 生成 naphthalen-1-yl-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone
  参考文献：
  名称：

  Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents

  摘要：

  A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.013
• 作为产物：
  描述：

  (4-methoxyphenyl)(naphthalen-1-yl)methanone 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 16.0h， 生成 [4-(2-Chloroethoxy)phenyl]-naphthalen-1-ylmethanone
  参考文献：
  名称：

  Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents

  摘要：

  A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.013

文献信息

• Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents
  作者：Atul Kumar、S.R. Pathak、Pervez Ahmad、S. Ray、P. Tewari、A.K. Srivastava

  DOI：10.1016/j.bmcl.2006.02.013

  日期：2006.5

  A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor. (C) 2006 Elsevier Ltd. All rights reserved.