2-(chloromethyl)-6-[[3-(chloromethyl)-2-hydroxy-5-methyl-phenyl]methyl]-4-methylphenol | 252062-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(chloromethyl)-6-[[3-(chloromethyl)-2-hydroxy-5-methyl-phenyl]methyl]-4-methylphenol
• 英文别名: 2-(3-chloromethyl-2-hydroxy-5-methylbenzyl)-6-chloromethyl-4-methylphenol；6,6'-bis-chloromethyl-4,4'-dimethyl-2,2'-methanediyl-di-phenol；6,6'-Bis-chlormethyl-4,4'-dimethyl-2,2'-methandiyl-di-phenol；Bis-(2-hydroxy-5-methyl-3-chlormethyl-phenyl)-methan；2-(Chloromethyl)-6-[[3-(chloromethyl)-2-hydroxy-5-methylphenyl]methyl]-4-methylphenol
• CAS: 252062-98-9
• 化学式: C₁₇H₁₈Cl₂O₂
• 分子量: 325.235
• InChiKey: SEOUHLSTOADLQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(chloromethyl)-6-[[3-(chloromethyl)-2-hydroxy-5-methyl-phenyl]methyl]-4-methylphenol 在 sodium acetate 作用下， 生成 α-Methyl-ω-(2-acetoxy-3,5-dimethylphenyl)-tris-(2-acetoxy-5-methyl-1,3-phenylen)-methylen
  参考文献：
  名称：

  The effects of grades on course enjoyment: Did you get the grade you wanted?

  摘要：

  Background. Students tend to rate university courses more positively if they do well. Greenwald and Gillmore (1997a) suggested that it is not students’ absolute grades that are important but rather how these grades compare to their expectations. However, this hypothesis is difficult to evaluate because few studies have measured grade expectations at the beginning of courses. Aim. By measuring students’ grade expectations and enjoyment at several stages during a course, we hoped to evaluate the extent to which expectations modulate the impact of grades on course enjoyment. Sample. Participants were 242 students in a university course in psychology. Method. Students were asked what grades they expected, and how much they were enjoying the course, at four stages. The effect of grades and grade expectations on enjoyment were analysed using restricted maximum likelihood (REML) and regression analyses. Results. The best predictor of course enjoyment varied somewhat at different stages, but in general it was the extent to which students’ grades surpassed their expectations. Students’ expectations at the beginning of the course proved particularly influential. Conclusions. Grade expectations do influence how students react to course grades, but the prominent role of pre‐course expectations suggests that it may be important to distinguish between grade aspirations and grade expectations. It appears to be students’ aspirations ‐ the grades they hope to achieve ‐ that most strongly shape their emotional reactions, rather than the more realistic expectations they may form later in a course.

  DOI：

  10.1348/000709900158173
• 作为产物：
  描述：

  2-(3-羟甲基-2-羟基-5-甲基苄基)-6-羟甲基-4-甲基苯酚 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 5.0h， 以80%的产率得到2-(chloromethyl)-6-[[3-(chloromethyl)-2-hydroxy-5-methyl-phenyl]methyl]-4-methylphenol
  参考文献：
  名称：

  具有氨基酸残基的手性双氮杂杂杯[4]芳烃的合成：具有酪氨酸残基的大环对外消旋铵离子的分子识别

  摘要：

  制备了含有氨基酸残基的手性比索二氮杂杯[4]芳烃。的1 H和13 C NMR谱表明，该大环化合物优选采用一个锥形构象，这表明该环芳基部分是在手性扭曲形式。圆二色性光谱支持环烷单元的手性的存在，并表明分子内氢键在手性从氨基酸残基到环烷部分的传递中起重要作用。带有酪氨酸残基的大环化合物具有一个足以容纳铵离子的π基腔，并且可以在1 H nmr分析过程中络合时用作外消旋铵离子的转移试剂。

  DOI：

  10.1002/jhet.5570370113

文献信息

• Dinuclear aluminum complexes supported by amino- or imino-phenolate ligands: synthesis, structures, and ring-opening polymerization catalysis of rac-lactide
  作者：Xiao-Feng Yu、Zhong-Xia Wang

  DOI：10.1039/c2dt32520a

  日期：——

  Two series of ligand precursors [2-OH-3-(CH2NR2)-5-MeC6H2]2CH2 (1: NR2 = NMe2; 2: NR2 = N(CH2)4; 3: NR2 = N(CH2)5; 4: NR2 = N(Me)Ph) and [2-OH-3-(CHNR)-5-MeC6H2]2CH2 (10: R = 2,6-Pri2C6H3; 11: R = p-MeC6H4; 12: R = p-ClC6H4; 13: R = p-MeOC6H4; 14: R = But) were prepared. These compounds reacted with AlMe3 to afford corresponding dinuclear aluminum complexes [AlMe22-O-3-(CH2NR2)-5-MeC6H2}]2CH2 (6: NR2 = NMe2; 7: NR2 = N(CH2)4; 8: NR2 = N(CH2)5; 9: NR2 = N(Me)Ph) and [AlMe22-O-3-(CHNR)-5-MeC6H2}]2CH2 (15: R = 2,6-Pri2C6H3; 16: R = p-MeC6H4; 17: R = p-ClC6H4; 18: R = p-MeOC6H4; 19: R = But). All the compounds were characterized by 1H and 13C NMR spectroscopy and elemental analyses. Complexes 6 and 16 were additionally characterized by single crystal X-ray diffraction techniques. Catalysis of the aluminum complexes towards the ring-opening polymerization of rac-lactide was evaluated in the presence of benzyl alcohol. All the polymerization reactions proceed in a controlled manner.

  两个系列的配体前体[2-OH-3-(CH2NR2)-5-MeC6H2]2CH2（1：NR2 = NMe2；2：NR2 = N(CH2)4；3：NR2 = N(CH2)5；4：NR2=N(Me)Ph）和[2-OH-3-(CHNR)-5-MeC6H2]2CH2（10：R=2,6-Pri2C6H3；11：R=p-MeC6H4；12：R=p-ClC6H4；13：R=p-MeOC6H4；14：R=But）。这些化合物与 AlMe3 反应生成相应的双核铝配合物 [AlMe22-O-3-(CH2NR2)-5-MeC6H2}]2CH2 （6：NR2 = NMe2；7：NR2 = N(CH2)4；8：9: NR2 = N(Me)Ph) 和 [AlMe22-O-3-(CHNR)-5-MeC6H2}]2CH2 (15: R = 2,6-Pri2C6H3; 16: R = p-MeC6H4; 17: R = p-ClC6H4; 18: R = p-MeOC6H4; 19: R = But)。所有化合物都通过 1H 和 13C NMR 光谱及元素分析进行了表征。此外，还利用单晶 X 射线衍射技术对络合物 6 和 16 进行了表征。在苯甲醇存在下，评估了铝络合物对 rac-内酰胺开环聚合反应的催化作用。所有聚合反应都以受控方式进行。
• Synthesis and properties of bowl-shaped homotriazacalix[3 and 6] arenes and the acyclic analogues
  作者：Kazuaki Ito、Tomokazu Sato、Yoshihiro Ohba

  DOI：10.1002/jhet.5570400110

  日期：2003.1

  Bowl-shaped chiral homotriazacalixarenes were prepared by the cyclization reactions of chiral triamines with three equimolar amounts of bis(chloromethyl) phenols or bis(chloromethyl) phenol-formaldehyde dimers in moderate yields. The corresponding acyclic phenol-formaldehyde oligomers were also synthesized. The structural analysis of the macrocycles by nmr and circular dichroism spectra imply the existence

  通过手性三胺与三个等摩尔量的双（氯甲基）苯酚或双（氯甲基）苯酚-甲醛二聚体的环化反应，制备了碗形手性高三氮杂壬基芳烃，其收率适中。还合成了相应的无环酚醛低聚物。通过NMR和圆二色性光谱对大环的结构分析表明存在从半胱氨酸桥的点手性到环烷部分的手性传递。它们的环状和非环状化合物的π基腔足够大，可以包含铵离子。
• Facile Formation of Chiral Calixarene Analogs Incorporating Cystine Peptide into the Macrocyclic Ring.
  作者：Kazuaki Ito、Takafumi Tamura、Kazuhito Watanabe、Yoshihiro Ohba

  DOI：10.1248/cpb.50.432

  日期：——

  Chiral calixarene analogs incorporating cystine peptide into their macrocyclic ring were easily prepared by the cyclization reactions of bis(chloromethyl)phenol-formaldehyde oligomers with cystine peptides in moderate yields. Circular dichroism (CD) spectra indicated the existence of the transmission of the chirality from peptide unit to phenol-formaldehyde oligomer moiety.

  通过将双（氯甲基）苯酚甲醛低聚物与胱氨酸肽进行环化反应，可以容易地制备将胱氨酸肽掺入其大环的手性杯芳烃类似物。圆二色性（CD）光谱表明手性从肽单元到酚-甲醛低聚物部分的传递存在。
• Synthesis and Properties of Chiral Tetrahomodiazacalix[4]- and -[6]arenes Bridged by a Cystine Unit
  作者：Kazuaki Ito、Yayoi Yamamori、Takanori Ohta、Yoshihiro Ohba

  DOI：10.1021/jo000738z

  日期：2000.12.1
• Synthesis of Chiral Tetrahomodiazacalix[4]-and [6]Arenes Bridged by Cystine Peptide
  作者：Kazuaki Ito、Yayoi Yamamori、Yoshihiro Ohba、Tyo Sone

  DOI：10.1080/00397910008087057

  日期：2000.12

  Bicyclic tetrahomodiazacalix[4]- and [6]arenes bridged by a cystine peptide were easily synthesized from the cyclization reactions of bis(chloromethyl)phenol-formaldehyde oligomers with cystine peptides in DMF in moderate yields.