4-thiophen-2-ylsulfanyl-butyric acid ethyl ester | 7675-08-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-thiophen-2-ylsulfanyl-butyric acid ethyl ester
• 英文别名: Ethyl 4-thiophen-2-ylsulfanylbutanoate；ethyl 4-thiophen-2-ylsulfanylbutanoate
• CAS: 7675-08-3
• 化学式: C₁₀H₁₄O₂S₂
• mdl: MFCD25967066
• 分子量: 230.352
• InChiKey: OTEBKGQOMUUWKX-UHFFFAOYSA-N

物化性质

• 熔点：
  168 °C
• 沸点：
  329.9±22.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-thiophen-2-ylsulfanyl-butyric acid ethyl ester 在 磷酸酐 、 氢氧化钾 、 Celite 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 4.0h， 生成 6,7-dihydro-5H-thieno<2,3-b>thiepin-4-one
  参考文献：
  名称：

  Synthesis and structure-activity analysis of 2-(4-chlorophenyl)-5,6-dihydrothieno[2′,3′:2,3]thiepino[4,5-c]pyridazin-3(2H)-ones as ligands for benzodiazepine receptors

  摘要：

  A series of 2-(4-chlorophenyl)-5,6-dihydrothieno[2',3':2,3]thiepino[4,5-c]pyridazin-3(2H)-ones were synthesized and evaluated in vitro for their affinity tow-ard benzodiazepine receptors (BZRs) in rats and for their intrinsic efficacy in the augmentation of the gamma-aminobutyric acid (GABA)-induced chloride currents in the dissociated frog sensory neurons. Compounds in which the 9-position of the condensed-ring system was substituted with alkyl group or bromine had a high affinity toward BZRs. The substituents at the same position also influenced significantly the GABA-induced chloride currents. As the result, 9-alkyl and 9-bromo substituents would interact with the lipophilic area of BZRs. A series of 2-(4-chlorophenyl)-5,6-dihydrothieno[2',3':2,3]thiepino[4,5-c]pyridazin-3(2H)-ones exhibited partial and full agonistic activities toward BZRs.

  DOI：

  10.1016/0223-5234(96)88305-x
• 作为产物：
  描述：

  4-羟基丁酸乙酯 在 sodium methylate 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 4-thiophen-2-ylsulfanyl-butyric acid ethyl ester
  参考文献：
  名称：

  硫醚穿心莲内酯衍生物的合成及其对癌细胞的抑制作用

  摘要：

  通过将各种芳族（或杂芳族）取代基掺入C-12或14-OH中，合成了一系列新颖的硫醚穿心莲内酯衍生物。总共制备了38种穿心莲内酯衍生物，并评估了它们对癌细胞的体外抑制活性。与母体化合物相比，所有衍生物均对前列腺癌细胞（PC-3）表现出更好的活性。在这些中，化合物6A中，8，9，17，19，31，和32显示出良好的活性。进一步评估了这些化合物对其他癌细胞系（包括MCF-7，MDA-MB-231和A549）的抗癌活性。化合物图31和图32显示了针对MCF-7的出色活性，IC 50值分别为0.7和0.6μM。通过单晶X射线衍射确定15a的绝对构型。15a的前体6a（12 S）的活性优于非对映异构体6b（12 R）的活性。此外，初步的结构-活动关系已被总结。本文获得的结果对于穿心莲内酯的进一步优化非常重要。

  DOI：

  10.1039/c7md00169j

文献信息

• Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells
  作者：Yi Liu、Ren-Ming Liang、Qing-Ping Ma、Kai Xu、Xin-Yong Liang、Wei Huang、Robert Sutton、Jie Ding、Paul M. O'Neil、Chun-Ru Cheng

  DOI：10.1039/c7md00169j

  日期：——

  A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibitory activity against cancer cells. All the derivatives exhibited better activity against prostate cancer cells (PC-3) than the parent compound. Among

  通过将各种芳族（或杂芳族）取代基掺入C-12或14-OH中，合成了一系列新颖的硫醚穿心莲内酯衍生物。总共制备了38种穿心莲内酯衍生物，并评估了它们对癌细胞的体外抑制活性。与母体化合物相比，所有衍生物均对前列腺癌细胞（PC-3）表现出更好的活性。在这些中，化合物6A中，8，9，17，19，31，和32显示出良好的活性。进一步评估了这些化合物对其他癌细胞系（包括MCF-7，MDA-MB-231和A549）的抗癌活性。化合物图31和图32显示了针对MCF-7的出色活性，IC 50值分别为0.7和0.6μM。通过单晶X射线衍射确定15a的绝对构型。15a的前体6a（12 S）的活性优于非对映异构体6b（12 R）的活性。此外，初步的结构-活动关系已被总结。本文获得的结果对于穿心莲内酯的进一步优化非常重要。
• Synthesis and structure-activity analysis of 2-(4-chlorophenyl)-5,6-dihydrothieno[2′,3′:2,3]thiepino[4,5-c]pyridazin-3(2H)-ones as ligands for benzodiazepine receptors
  作者：H Tanaka、S Kirihara、H Yasumatsu、T Yakushiji、T Nakao

  DOI：10.1016/0223-5234(96)88305-x

  日期：1995.1

  A series of 2-(4-chlorophenyl)-5,6-dihydrothieno[2',3':2,3]thiepino[4,5-c]pyridazin-3(2H)-ones were synthesized and evaluated in vitro for their affinity tow-ard benzodiazepine receptors (BZRs) in rats and for their intrinsic efficacy in the augmentation of the gamma-aminobutyric acid (GABA)-induced chloride currents in the dissociated frog sensory neurons. Compounds in which the 9-position of the condensed-ring system was substituted with alkyl group or bromine had a high affinity toward BZRs. The substituents at the same position also influenced significantly the GABA-induced chloride currents. As the result, 9-alkyl and 9-bromo substituents would interact with the lipophilic area of BZRs. A series of 2-(4-chlorophenyl)-5,6-dihydrothieno[2',3':2,3]thiepino[4,5-c]pyridazin-3(2H)-ones exhibited partial and full agonistic activities toward BZRs.