6-isopropoxy-1,2,3,4-tetrahydro-isoquinoline | 1342992-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6-isopropoxy-1,2,3,4-tetrahydro-isoquinoline
• 英文别名: 6-Isopropoxy-1,2,3,4-tetrahydroisoquinoline；6-propan-2-yloxy-1,2,3,4-tetrahydroisoquinoline
• CAS: 1342992-17-9
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: FRDFZXQDIJMKGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-氯-N-(6-甲基吡啶-2-基)烟酰胺 、 6-isopropoxy-1,2,3,4-tetrahydro-isoquinoline 以 异丙醇 为溶剂， 反应 48.0h， 以10%的产率得到N-(6-methylpyridin-2-yl)-6-(6-propan-2-yloxy-3,4-dihydro-1H-isoquinolin-2-yl)pyridine-3-carboxamide
  参考文献：
  名称：

  SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

  摘要：

  Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, 7au and 7bb, as promising candidates of second generation AR antagonists for advanced prostate cancer.

  DOI：

  10.1021/jm3014103
• 作为产物：
  描述：

  6-甲氧基-1,2,3,4-四氢异喹啉盐酸盐 在 盐酸 、 水 、 氢溴酸 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 水 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 13.0h， 生成 6-isopropoxy-1,2,3,4-tetrahydro-isoquinoline
  参考文献：
  名称：

  SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

  摘要：

  Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, 7au and 7bb, as promising candidates of second generation AR antagonists for advanced prostate cancer.

  DOI：

  10.1021/jm3014103

文献信息

• Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereof
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160075657A1

  公开（公告）日：2016-03-17

  The invention relates to new pyrrolidine derivatives of the formula wherein R 1 to R 6 , n and m are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及新的吡咯烷衍生物，其化学式如下：其中R1至R6，n和m的定义如说明书和权利要求书中所述，以及它们作为药物的用途，它们的治疗用途的方法以及包含它们的制药组合物。
• TETRAHYDROISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR THE TREATMENT OF OBESITY AND DIABETES
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3194367B1

  公开（公告）日：2021-08-18
• US9340510B2
  申请人：——

  公开号：US9340510B2

  公开（公告）日：2016-05-17
• SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer
  作者：Su Hui Yang、Chin-Hee Song、Hue Thi My Van、Eunsook Park、Daulat Bikram Khadka、Eun-Yeung Gong、Keesook Lee、Won-Jea Cho

  DOI：10.1021/jm3014103

  日期：2013.4.25

  Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, 7au and 7bb, as promising candidates of second generation AR antagonists for advanced prostate cancer.