4-(2,5-dichloro-phenylsulfanyl)-butyric acid | 29193-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,5-dichloro-phenylsulfanyl)-butyric acid
• 英文别名: 4-(2,5-dichlorophenyl)sulfanylbutanoic acid
• CAS: 29193-64-4
• 化学式: C₁₀H₁₀Cl₂O₂S
• 分子量: 265.16
• InChiKey: DNAJRCXMYQPXPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2,5-dichloro-phenylsulfanyl)-butyric acid 在 双氧水 、 溶剂黄146 作用下， 生成 Butanoic acid, 4-[(2,5-dichlorophenyl)sulfonyl]-
  参考文献：
  名称：

  Kukalenko,S.S., Journal of Organic Chemistry USSR (English Translation), 1970, vol. 6, p. 682 - 685

  摘要：

  DOI：
• 作为产物：
  描述：

  γ-丁内酯 、 sodium salt of 2,5-dichlorobenzenethiol 生成 4-(2,5-dichloro-phenylsulfanyl)-butyric acid
  参考文献：
  名称：

  Kukalenko,S.S., Journal of Organic Chemistry USSR (English Translation), 1970, vol. 6, p. 682 - 685

  摘要：

  DOI：

文献信息

• ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
  申请人：Pusztay Stephen

  公开号：US20090258817A1

  公开（公告）日：2009-10-15

  Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

  提供用于传递活性剂的化合物和组合物。还提供了给药和制备方法。
• A Monoclonal Immunoassay for the Coplanar Polychlorinated Biphenyls
  作者：Ya-Wen. Chiu、Robert E. Carlson、Karen L. Marcus、Alexander E. Karu

  DOI：10.1021/ac00117a003

  日期：1995.11.1

  Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants with diverse toxic, teratogenic, reproductive, immunotoxic, and tumorigenic effects, Three of the least abundant of the 209 PCB isomers (congeners) are the most toxic and most difficult to quantify, These are 3,4,3',4'-tetrachlorobiphenyl, 3,4,3',4',5'-pentachlorobiphetayl, and 3,4,5,3',4',5'-hexachlorobiphenyl (IUPAC No, 77, 126, and 169, respectively), An immunizing hapten was designed to retain the 3,4,3',4' chlorine-substitution pattern and coplanarity characteristic of these toxic congeners, The optimal competitors for immunoassay were weaker binding distinctive single-ring fragments of the PCBs, A monoclonal antibody designated S2B1 was derived and used in direct (antibody-capture) competitive enzyme immunoassays (EIAs). The EIAs are highly specific for non-ortho-substituted congeners and do not recognize the more prevalent but much less toxic noncoplanar PCB congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, or dichlorobenzenes, Hapten and competitor design for this assay suggests a basis for development of sensitive EIAs for other classes of PCB congeners.
• US9873667B2
  申请人：——

  公开号：US9873667B2

  公开（公告）日：2018-01-23
• [EN] ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS<br/>[FR] COMPOSÉS ARYLSULFANYLÉS ET COMPOSITIONS POUR ADMINISTRER DES AGENTS ACTIFS
  申请人：EMISPHERE TECH INC

  公开号：WO2008014430A1

  公开（公告）日：2008-01-31

  [EN] Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.
  [FR] L'invention concerne des composés et des compositions pour l'administration d'agents actifs. L'invention concerne également des procédés d'administration et de préparation.
• Kukalenko,S.S., Journal of Organic Chemistry USSR (English Translation), 1970, vol. 6, p. 682 - 685
  作者：Kukalenko,S.S.

  DOI：——

  日期：——