(E)-1,2-bis(4-methoxyphenyl)-1,2-diphenylethene | 68578-78-9

• 物质功能分类: 化学试剂 - 有机试剂 - 烯烃（环状与无环状）
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1,2-bis(4-methoxyphenyl)-1,2-diphenylethene
• 英文别名: 1,2-Bis(4-methoxyphenyl)-1,2-diphenylethene；1-methoxy-4-[(E)-2-(4-methoxyphenyl)-1,2-diphenylethenyl]benzene
• CAS: 68578-78-9
• 化学式: C₂₈H₂₄O₂
• 分子量: 392.497
• InChiKey: SJCRDTOTGDVNJD-BYYHNAKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  (E)-1,2-bis(4-methoxyphenyl)-1,2-diphenylethene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 1,2-二(4-羟基苯)-1,2-二苯乙烯
  参考文献：
  名称：

  Imidazole-bearing tetraphenylethylene: fluorescent probe for metal ions based on AIE feature

  摘要：

  在四氢呋喃-水混合物中，含咪唑的四苯基乙烯悬浮液具有聚集诱发的发射特征，水份含量高，发射率高，由于咪唑分子与 Fe3+ 离子之间的配位，Fe3+ 离子可以完全淬灭咪唑。

  DOI：

  10.1039/c1nj20122k
• 作为产物：
  描述：

  4-methoxythiobenzophenone 在 aluminum oxide 、 三乙基硼氢化钠 、 iron(II) chloride 作用下， 以 四氢呋喃 、 苯 为溶剂， 以76%的产率得到(E)-1,2-bis(4-methoxyphenyl)-1,2-diphenylethene
  参考文献：
  名称：

  Desulfurization of thiols and thioketones by sodium triethylborohydride and iron(II) chloride on alumina

  摘要：

  DOI：

  10.1021/jo00150a020

文献信息

• A heterobimetallic complex featuring a Ti–Co multiple bond and its application to the reductive coupling of ketones to alkenes
  作者：Bing Wu、Mark W. Bezpalko、Bruce M. Foxman、Christine M. Thomas

  DOI：10.1039/c4sc03772c

  日期：——

  To explore metal–metal multiple bonds between first row transition metals, Ti/Co complexes supported by two phosphinoamide ligands have been synthesized and characterized. The Ti metalloligand Cl2Ti(XylNPiPr2)2 (1) was treated with CoI2 under reducing conditions, permitting isolation of the Ti/Co complex [(μ-Cl)Ti(XylNPiPr2)2CoI]2 (2). One electron reduction of complex 2 affords ClTi(XylNPiPr2)2CoPMe3

  为了探索第一行过渡金属之间的金属-金属多重键，合成并表征了由两个膦酰胺配体支持的 Ti/Co 配合物。Ti金属配体Cl 2 Ti(XylNP i Pr 2 ) 2 ( 1 )在还原条件下用CoI 2处理，允许分离Ti/Co络合物[(μ-Cl)Ti(XylNP i Pr 2 ) 2 CoI] 2 ( 2 )。配合物2的一个电子还原得到 ClTi(XylNP i Pr 2 ) 2 CoPMe 3 ( 3)，它具有金属-金属三键和空前短的 2.0236(9) Å 的 Ti-Co 距离。该配合物可促进芳基酮与烯烃的 McMurry 偶联反应，同时形成四核配合物 [Ti(μ 3 -O)(NXylP i Pr 2 ) 2 CoI] 2 ( 4 )。提出了一种涉及双金属CO键活化和钴卡宾中间体的协同机制。
• Nickel-Catalyzed Three-Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes
  作者：Fei Xue、Jin Zhao、T. S. Andy Hor、Tamio Hayashi

  DOI：10.1021/ja513166w

  日期：2015.3.11

  Three-component reaction of aryl Grignard reagents, alkynes, and aryl halides in the presence of 1 mol % of NiCl2 proceeded sequentially through carbomagnesiation of the alkyne followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetrasubstituted alkenes in high yields.

  在 1 mol % NiCl2 存在下芳基格氏试剂、炔烃和芳基卤化物的三组分反应依次通过炔烃的碳镁化反应进行，然后将所得烯基格氏试剂与芳基卤化物交叉偶联，得到四取代的烯烃。产量。
• WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN
  申请人：TANG Benzhong

  公开号：US20120172296A1

  公开（公告）日：2012-07-05

  The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.

  目前描述的主题涉及水溶性共轭聚烯烃化合物及其衍生物，这些化合物表现出聚集诱导发光，以及任何水分散的荧光聚合微粒、纳米粒子和/或含有水溶性共轭聚烯烃化合物和/或其衍生物的药物组合物。还提供了制备和使用目前描述的主题的化合物、衍生物和颗粒的方法。目前描述的水溶性共轭聚烯烃化合物可用作生物探针，用于检测生物大分子，在传感器的制造中，用于监测和延缓体外和体内淀粉样蛋白纤维的形成，以及用于开发抗癌药物。
• Low-valent titanium induced reductive coupling reaction of carboxylic derivatives with aromatic ketones
  作者：Da-qing Shi、Jian-xie Chen、Wen-ying Chai、Wei-xing Chen、Tsi-yu Kao

  DOI：10.1016/s0040-4039(00)60493-8

  日期：1993.4

  The intermolecular and intramolecular coupling reaction of carboxylic derivaties with aromatic ketones induced by titanium tetrachloride and zinc powder was studied.

  研究了四氯化钛和锌粉诱导的羧酸衍生物与芳族酮的分子间和分子内偶联反应。
• Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same
  申请人：Tang Benzhong

  公开号：US20080220407A1

  公开（公告）日：2008-09-11

  The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene compounds are useful as bioprobes for the detection biomacromolecules, as well as in the manufacture of sensors.

  目前所描述的主题涉及具有聚集诱导发光性质的水溶性共轭聚烯烃化合物，以及包含这些水溶性共轭聚烯烃化合物的水分散荧光聚合微粒和/或纳米粒子。还提供了制备和使用这些化合物和微粒子的方法。所述的共轭聚烯烃化合物可用作检测生物大分子的生物探针，以及制造传感器的材料。