Conformational studies of tertiary oligo-m-benzanilides and oligo-p-benzanilides in solution
摘要:
A series of oligo-m- and p-benzanilides were made and their conformations in solution were studied by NMR. In most cases, conformational mixtures were observed as soon as three or more monomers were incorporated into the oligomer. Some crystal structures were obtained, which indicated that helical conformations were adopted in the solid state. (C) 2010 Elsevier Ltd. All rights reserved.
[EN] MODIFIED PROTEINS AND PROTEIN DEGRADERS<br/>[FR] PROTÉINES MODIFIÉES ET AGENTS DE DÉGRADATION DE PROTÉINES
申请人:[en]CULLGEN (SHANGHAI), INC.
公开号:WO2023061440A1
公开(公告)日:2023-04-20
Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are bifunctional compounds having a DNA damage-binding protein 1 (DDB1) binding moiety, a linker, and a target binding moiety.