(Z)-2-(bromo(2-chlorophenyl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one | 1204607-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (Z)-2-(bromo(2-chlorophenyl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
• CAS: 1204607-41-9
• 化学式: C₁₈H₁₄BrClO₃
• 分子量: 393.664
• InChiKey: FNWKDJCDPAPSHT-LGMDPLHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (Z)-2-(bromo(2-chlorophenyl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 生成 2-(2-chlorobenzoyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Synthesis and antimycobacterial evaluation of novel 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-5,4-substituted phenyl methanone analogues

  摘要：

  In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenylmethanone analogues were synthesized and were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv and INH resistant M. tuberculosis. All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-4-fluorophenylmethanone (5g) was found to be the most promising compounds active against M. tuberculosis H(37)Rv and isoniazid (INH) resistant M. tuberculosis with Minimum inhibitory concentration 0.10 and 0.10 mu M. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.034
• 作为产物：
  描述：

  (E)-2-(2-chlorobenzylidene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 在 HCl*Br₂ 作用下， 以 氯仿 为溶剂， 生成 (Z)-2-(bromo(2-chlorophenyl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues

  摘要：

  In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7 +/- 0.01 mu mol/L. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.042