(+-)-4a-hydroxy-cis-4,4a,9,9a-tetrahydro-3H-indeno[2,1-b]pyran-2-one | 107058-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (+-)-4a-hydroxy-cis-4,4a,9,9a-tetrahydro-3H-indeno[2,1-b]pyran-2-one
• 英文别名: (+/-)-4a-hydroxy-cis-4,4a,9,9a-tetrahydro-3H-indeno[2,1-b]pyran-2-one；(+/-)-4a-Hydroxy-cis-4,4a,9,9a-tetrahydro-3H-indeno[2,1-b]pyran-2-on
• CAS: 107058-08-2
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: WQNBLQSUEBAXRA-ZYHUDNBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  15.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-inden-3-yl-propionic acid ethyl ester 在 sodium hydroxide 、 甲酸 、 氯仿 、 双氧水 作用下， 生成 (+-)-4a-hydroxy-cis-4,4a,9,9a-tetrahydro-3H-indeno[2,1-b]pyran-2-one
  参考文献：
  名称：

  February asthma outbreaks in NSW: a case control study

  摘要：

  Objectives: To investigate individual factors associated with an asthma outbreak among children aged one to 14 years in Sydney in February 1999. Methods: A case control study was undertaken with cases (n=92) defined as all children admitted to Sydney Children's Hospital for asthma in February 1999. Unmatched controls (n=76) were all children admitted for asthma in the previous three months. We obtained information by a structured telephone survey of parents. Logistic regression analyses were used to determine odds ratios for risk factors for hospital admission. Results: Mean age for hospital admission of 4.7 years for cases and 4.4 years for controls. The presence of one or more siblings reduced the risk of admission during an asthma outbreak (OR=0.59, 95% Cl 0.37 to 0.93). Children with older siblings aged 10 to 14 years were also less likely to be admitted (OR=0.3, 95% Cl 0.12 to 0.74). An age effect was observed. Other demographic, clinical and environmental characteristics, including smoking, were not associated with admission during the outbreak. Conclusions: The main findings of this study are the protective effect of siblings and an age-dependent effect in risk of hospital admission during an asthma outbreak. These findings are consistent with an infective cause of the outbreak. Implications: Children without siblings, particularly older siblings, appear to be at highest risk of hospital admission during an asthma outbreak. Environmental and other factors need to be examined to further explain the episodicity of such outbreaks and to determine means of predicting and preventing future episodes.

  DOI：

  10.1111/j.1467-842x.2001.tb00315.x