2,3-二氨基-9H-芴-9-酮 | 6633-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 2,3-二氨基-9H-芴-9-酮
• 英文名称: 2,3-diamino-fluoren-9-one
• 英文别名: 2,3-Diamino-fluoren-9-on；2,3-Diamino-9h-fluoren-9-one；2,3-diaminofluoren-9-one
• CAS: 6633-42-7
• 化学式: C₁₃H₁₀N₂O
• 分子量: 210.235
• InChiKey: MSURJSLHFVCZLX-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C
• 沸点：
  497.4±38.0 °C(Predicted)
• 密度：
  1.407±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  2,3-二氨基-9H-芴-9-酮 在 碘 、 溶剂黄146 作用下， 生成 indeno[1,2-b]phenazin-11-one
  参考文献：
  名称：

  238. 2-硝基芴酮与氢氧化钾，苯胺和苯胺钠的反应

  摘要：

  DOI：

  10.1039/jr9590001205
• 作为产物：
  描述：

  (9-oxo-fluoren-2-yl)-carbamic acid ethyl ester 在 sodium sulfide 、 sodium hydroxide 、 硫酸 、 硝酸 、 溶剂黄146 作用下， 生成 2,3-二氨基-9H-芴-9-酮
  参考文献：
  名称：

  Eckert; Langecker, Journal fur praktische Chemie (Leipzig 1954), 1928, vol. <2> 118, p. 269

  摘要：

  DOI：

文献信息

• Heterocyclic-hydroxyimino-fluorene nuclei compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
  申请人：——

  公开号：US20020049238A1

  公开（公告）日：2002-04-25

  Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

  本文描述了具有杂环-羟基亚氨基-芴核的化合物，可调节和/或抑制某些蛋白激酶的活性。这些化合物和含有它们的药物组合物能够介导酪氨酸激酶信号转导，以调节和/或抑制不需要的细胞增殖。本发明还涉及含有此类化合物的药物组合物的治疗或预防用途，以及通过施用有效量的此类化合物来治疗癌症和其他与不必要的血管生成和/或细胞增殖相关的疾病状态（如糖尿病视网膜病变、青光眼、类风湿性关节炎和牛皮癣）的方法。
• HETEROCYCLIC-HYDROXYIMINO-FLUORENES AND THEIR USE FOR INHIBITING PROTEIN KINASES
  申请人：Agouron Pharmaceuticals, Inc.

  公开号：EP1309563A1

  公开（公告）日：2003-05-14
• US6462060B2
  申请人：——

  公开号：US6462060B2

  公开（公告）日：2002-10-08
• [EN] HETEROCYCLIC-HYDROXYIMINO-FLUORENES AND THEIR USE FOR INHIBITING PROTEIN KINASES<br/>[FR] HYDROXYIMINO-FLUORENES HETEROCYCLIQUES ET LEUR UTILISATION POUR INHIBER DES PROTEINES KINASES
  申请人：AGOURON PHARMA

  公开号：WO2002016326A1

  公开（公告）日：2002-02-28

  Compunds of the formula I or II wherein X is CY or N, and W is O or S, modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
• Eckert; Langecker, Journal fur praktische Chemie (Leipzig 1954), 1928, vol. <2> 118, p. 269
  作者：Eckert、Langecker

  DOI：——

  日期：——

表征谱图