1,4-Anthracenedione, 2-hydroxy- | 610-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,4-Anthracenedione, 2-hydroxy-
• 英文别名: 2-hydroxy-1,4-anthracenedione；2-hydroxyanthracene-1,4-dione；2-hydroxy-anthracene-1,4-dione；2-Hydroxy-anthracen-1,4-dion；2-hydroxy-1,4-anthraquinone
• CAS: 610-21-9
• 化学式: C₁₄H₈O₃
• 分子量: 224.216
• InChiKey: WCHCQWVIGFSPFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  17.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.37
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  乙酸乙烯酯 、 1,4-Anthracenedione, 2-hydroxy- 以 丙酮 为溶剂， 反应 0.83h， 以63%的产率得到2-acetoxy-2,3-dihydroanthra<2,3-b>furan-4,11-dione
  参考文献：
  名称：

  Kobayashi, Kazuhiro; Kujime, Sachiko; Suginome, Hiroshi, Heterocycles, 1992, vol. 33, # 2, p. 553 - 562

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 1,4-Anthracenedione, 2-hydroxy-
  参考文献：
  名称：

  Fieser, Journal of the American Chemical Society, 1928, vol. 50, p. 467

  摘要：

  DOI：

文献信息

• Unusual, chemoselective etherification of 2-hydroxy-1,4-naphthoquinone derivatives utilizing alkoxymethyl chlorides: scope, mechanism and application to the synthesis of biologically active natural product (±)-lantalucratin C
  作者：Tokutaro Ogata、Tomoyo Yoshida、Maki Shimizu、Manami Tanaka、Chie Fukuhara、Junko Ishii、Arisa Nishiuchi、Kiyofumi Inamoto、Tetsutaro Kimachi

  DOI：10.1016/j.tet.2016.01.040

  日期：2016.3

  A novel etherification of 2-hydroxy-1,4-naphthoquinone derivatives with alkoxyalkyl chlorides and hydride bases is described. Precise study of the conditions and substrate scope suggested that the reaction occurs specifically in the molecule having a 2-hydroxy-1,4-benzoquinone skeleton. A chemoselective O-methylation reaction was achieved to afford a synthetically important intermediate, which offered

  描述了2-羟基-1，4-萘醌衍生物与烷氧基烷基氯化物和氢化物碱的新型醚化。对条件和底物范围的精确研究表明，该反应特别发生在具有2-羟基-1,4-苯醌骨架的分子中。实现了化学选择性的O-甲基化反应，以提供合成上重要的中间体，该中间体可轻松获得具有抗肿瘤活性的天然产物。
• Palladium-catalyzed enol/enolate directed oxidative annulation: functionalized naphthofuroquinone synthesis and bioactivity evaluation
  作者：Shuaipeng Lv、Haitao Liu、Jie Kang、Yun Luo、Ting Gong、Zhengqi Dong、Guibo Sun、Chunnian He、Xiaobo Sun、Lei Wang

  DOI：10.1039/c9cc05233j

  日期：——

  A palladium-promoted oxidative annulation reaction for the synthesis of structurally diverse naphthoquinone-containing heterocycles has been developed, providing switchable access to 1,2-naphthofuroquinones and densely functionalized cyclobutene-fused 1,4-naphthofuroquinones by selective enol/enolate-directed processes. The synthetic application was extended by late-stage functionalization of an anti-HIV

  已经开发了用于合成结构多样的含萘醌的杂环的钯促进的氧化环化反应，通过选择性的烯醇/烯醇酸酯定向方法提供了可转换的途径来接近1,2-萘呋喃醌和稠密官能化的环丁烯稠合的1,4-萘呋喃醌。合成的应用通过抗HIV药物的后期功能化得以扩展。1,2-萘呋喃醌合成的实用价值在内皮保护性先导化合物的开发中得到了强调。
• Reductant precursor for tellurium imaging compositions
  申请人：Energy Conversion Devices, Inc.

  公开号：US04532078A1

  公开（公告）日：1985-07-30

  Imaging films and film-forming compositions are provided which include a reducible tellurium compound, a reductant precursor, a source of labile hydrogen incorporated in a matrix. The reductant precursors are of the formulae ##STR1## where Y.sub.1 is alkoxy, Y.sub.2 is chloro or alkoxy and Y.sub.3 is hydrogen, chloro or alkoxy. Methods are provided for synthesizing the reductant precursors.

  提供了包括可还原碲化合物、还原剂前体、在基质中包含不稳定氢源的成像薄膜和制膜组合物。还原剂前体的化学式为##STR1##其中，Y.sub.1为烷氧基，Y.sub.2为氯或烷氧基，Y.sub.3为氢、氯或烷氧基。还提供了合成还原剂前体的方法。
• Tellurium imaging composition including improved reductant precursor and
  申请人：Energy Conversion Devices, Inc.

  公开号：US04698184A1

  公开（公告）日：1987-10-06

  Imaging films and film-forming compositions are provided which include a reducible tellurium compound, a reductant precursor, a source of labile hydrogen incorporated in a matrix. The reductant precursors are of the formulae ##STR1## where Y.sub.1 is alkoxy, Y.sub.2 is chloro or alkoxy and Y.sub.3 is hydrogen, chloro or alkoxy. Methods are provided for synthesizing the reductant precursors.

  提供了包括可还原碲化合物、还原剂前体、含有易变氢源的基质的成像胶片和制膜组合物。还原剂前体的化学式为##STR1##其中，Y.sub.1为烷氧基，Y.sub.2为氯或烷氧基，Y.sub.3为氢、氯或烷氧基。提供了合成还原剂前体的方法。
• Imaging film and film-forming composition, method for recording electromagnetic radiation, quinone compounds and method of synthesizing quinone compounds
  申请人：ENERGY CONVERSION DEVICES, INC.

  公开号：EP0098020A2

  公开（公告）日：1984-01-11

  Imaging films and film-forming compositions are provided which include a reducible tellurium compound, a reductant precursor, a source of labile hydrogen incorporated in a matrix. The reductant precursors are of the formulae or where Y1 is alkoxy, Y2 is chloro or alkoxy and Y3 is hydrogen, chloro or alkoxy. Methods are provided for synthesizing the reductant precursors.

  提供了成像薄膜和成膜组合物，其中包括一种可还原的碲化合物、一种还原剂前体、一种结合在基质中的易变氢源。 还原剂前体的式子为 Y1 是烷氧基，Y2 是氯或烷氧基，Y3 是氢、氯或烷氧基。 提供了合成还原剂前体的方法。