N-(6-benzyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-chloro-5-(2-(2,2,2-trifluoroacetamido)ethoxy)benzamide | 1565758-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(6-benzyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-chloro-5-(2-(2,2,2-trifluoroacetamido)ethoxy)benzamide
• 英文别名: N-(6-benzyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2-chloro-5-[2-[(2,2,2-trifluoroacetyl)amino]ethoxy]benzamide
• CAS: 1565758-91-9
• 化学式: C₂₆H₂₂ClF₃N₄O₃S
• 分子量: 563.0
• InChiKey: UPWXBCLSIYAIEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-(6-benzyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-chloro-5-(2-(2,2,2-trifluoroacetamido)ethoxy)benzamide 在 三乙胺 、 mercury dichloride 、 sodium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 tert-butyl (tert-butoxycarbonylamino)(2-(4-chloro-3-(3-cyano-6-(benzyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-ylcarbamoyl)phenoxy)ethylamino)methylenecarbamate
  参考文献：
  名称：

  Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold

  摘要：

  MurF ligase is a crucial enzyme that catalyses the ultimate intracellular step of bacterial peptidoglycan biosynthesis, and thus represents an attractive target for antibacterial drug discovery. We designed, synthesized and evaluated a new series of cyanothiophene-based inhibitors of MurF enzymes from Streptococcus pneumoniae and Escherichia colt. The target compounds had increased polarity compared to the first generation of inhibitors, with demonstrated enzyme inhibitory potencies in the low micromolar range. Furthermore, the best inhibitors displayed promising antibacterial activities against selected Gram-positive and Gram-negative strains. These results represent an important step towards the development of new antibacterial agents targeting peptidoglycan biosynthesis. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.11.031
• 作为产物：
  描述：

  2-氯-5-羟基苯甲酸甲酯 在 吡啶 、 草酰氯 、 potassium carbonate 、 三乙胺 、 N,N-二甲基甲酰胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.84h， 生成 N-(6-benzyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-chloro-5-(2-(2,2,2-trifluoroacetamido)ethoxy)benzamide
  参考文献：
  名称：

  Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold

  摘要：

  MurF ligase is a crucial enzyme that catalyses the ultimate intracellular step of bacterial peptidoglycan biosynthesis, and thus represents an attractive target for antibacterial drug discovery. We designed, synthesized and evaluated a new series of cyanothiophene-based inhibitors of MurF enzymes from Streptococcus pneumoniae and Escherichia colt. The target compounds had increased polarity compared to the first generation of inhibitors, with demonstrated enzyme inhibitory potencies in the low micromolar range. Furthermore, the best inhibitors displayed promising antibacterial activities against selected Gram-positive and Gram-negative strains. These results represent an important step towards the development of new antibacterial agents targeting peptidoglycan biosynthesis. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.11.031

文献信息

• Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold
  作者：Martina Hrast、Marko Anderluh、Damijan Knez、Christopher P. Randall、Hélène Barreteau、Alex J. O'Neill、Didier Blanot、Stanislav Gobec

  DOI：10.1016/j.ejmech.2013.11.031

  日期：2014.2

  MurF ligase is a crucial enzyme that catalyses the ultimate intracellular step of bacterial peptidoglycan biosynthesis, and thus represents an attractive target for antibacterial drug discovery. We designed, synthesized and evaluated a new series of cyanothiophene-based inhibitors of MurF enzymes from Streptococcus pneumoniae and Escherichia colt. The target compounds had increased polarity compared to the first generation of inhibitors, with demonstrated enzyme inhibitory potencies in the low micromolar range. Furthermore, the best inhibitors displayed promising antibacterial activities against selected Gram-positive and Gram-negative strains. These results represent an important step towards the development of new antibacterial agents targeting peptidoglycan biosynthesis. (C) 2013 Elsevier Masson SAS. All rights reserved.