1,4-Anthracendicarbonsaeure-dimethylester | 58791-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,4-Anthracendicarbonsaeure-dimethylester
• 英文别名: 1,4-Anthracenedicarboxylic acid dimethyl ester；dimethyl anthracene-1,4-dicarboxylate
• CAS: 58791-46-1
• 化学式: C₁₈H₁₄O₄
• 分子量: 294.307
• InChiKey: IMKGNZDIKBKXLD-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C(Solv: ligroine (8032-32-4))
• 沸点：
  473.1±18.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-Anthracendicarbonsaeure-dimethylester 在 sodium cyanoborohydride 、 红铝 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 30.0h， 生成 N-[[4-[[2-(dimethylamino)ethylamino]methyl]anthracen-1-yl]methyl]-N',N'-dimethylethane-1,2-diamine
  参考文献：
  名称：

  1,4-Disubstituted Anthracene Antitumor Agents

  摘要：

  Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug-resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino>ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4-diamide was more potent across the tumor panel than the corresponding 9,10-isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,Li-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.

  DOI：

  10.1021/jm970308+
• 作为产物：
  描述：

  9,10-dioxo-9,10-dihydro-1,4-anthracene dicarboxylic acid 在 盐酸 、 ammonium hydroxide 、 锌 作用下， 生成 1,4-Anthracendicarbonsaeure-dimethylester
  参考文献：
  名称：

  1,4-Disubstituted Anthracene Antitumor Agents

  摘要：

  Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug-resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino>ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4-diamide was more potent across the tumor panel than the corresponding 9,10-isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,Li-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.

  DOI：

  10.1021/jm970308+

文献信息

• PHOTOSENSITIVE COMPOSITION, PLANOGRAPHIC PRINTING PLATE PRECURSOR, POLYURETHANE, AND METHOD FOR PRODUCING POLYURETHANE
  申请人：FUJIFILM CORPORATION

  公开号：US20140134540A1

  公开（公告）日：2014-05-15

  A photosensitive composition includes (A) a polyurethane obtained by reacting a diol component including a compound represented by the following Formula (I) with a polyisocyanate component; and (B) a photosensitive component. In Formula (I), A represents a single bond, or a divalent linking group including an atom selected from the group consisting of a carbon atom, a hydrogen atom, and an oxygen atoms; B represents a monovalent organic group; each of R 1 to R 5 independently represents a hydrogen atom or an alkyl group; m represents an integer from 0 to 3; n represents an integer from 0 to 3; and m+n is not zero.

  一种光敏组合物，包括(A)聚氨酯和(B)光敏组分。聚氨酯是通过将包括以下式(I)的化合物的二元醇组分与多异氰酸酯组分反应而获得的。在式(I)中，A表示单键，或者包括从群组中选择的原子的双价连接基团，该群组包括碳原子，氢原子和氧原子；B表示单价有机基团；R1到R5中的每一个独立地表示氢原子或烷基；m表示从0到3的整数；n表示从0到3的整数；且m+n不为零。
• PHOTOSENSITIVE COMPOSITION, MASTER PLATE FOR PLANOGRAPHIC PRINTING PLATE, POLYURETHANE, AND METHOD FOR PRODUCING POLYURETHANE
  申请人：Fujifilm Corporation

  公开号：EP2725422A1

  公开（公告）日：2014-04-30

  A photosensitive composition includes (A) a polyurethane obtained by reacting a diol component including a compound represented by the following Formula (I) with a polyisocyanate component; and (B) a photosensitive component. In Formula (I), A represents a single bond, or a divalent linking group including an atom selected from the group consisting of a carbon atom, a hydrogen atom, and an oxygen atoms; B represents a monovalent organic group; each of R1 to R5 independently represents a hydrogen atom or an alkyl group; m represents an integer from 0 to 3; n represents an integer from 0 to 3; and m + n is not zero.

  一种感光组合物包括：(A) 一种聚氨酯，由二元醇组分（包括下式(I)所代表的化合物）与多异氰酸酯组分反应而得；(B) 一种感光组分。在式（I）中，A 代表单键，或二价连接基团，包括从碳原子、氢原子和氧原子组成的组中选出的原子；B 代表一价有机基团；R1 至 R5 中的每一个独立地代表氢原子或烷基；m 代表 0 至 3 的整数；n 代表 0 至 3 的整数；且 m + n 不为零。
• Gundermann,K.-D.; Roeker,K.-D., Justus Liebigs Annalen der Chemie, 1976, p. 140 - 152
  作者：Gundermann,K.-D.、Roeker,K.-D.

  DOI：——

  日期：——
• PHOTOSENSITIVE COMPOSITION, MASTER PLATE FOR PLANOGRAPHIC PRINTING PLATE AND POLYURETHANE
  申请人：Fujifilm Corporation

  公开号：EP2725422B1

  公开（公告）日：2017-10-04
• US8927195B2
  申请人：——

  公开号：US8927195B2

  公开（公告）日：2015-01-06