1-[(3S,4R,5S)-5-hydroxy-4-methyloxolan-3-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 1-[(3S,4R,5S)-5-hydroxy-4-methyloxolan-3-yl]ethanone
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: CLYSZQBIUYRLNX-QXRNQMCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 α-(+)-botryodiplodin acetate 在 Lipase PS 作用下， 以 氯仿 为溶剂， 反应 192.0h， 生成 乙酸甲酯 、 (+)-botryodiplodin 、 (+)-botryodiplodin 、 1-[(3S,4R,5S)-5-hydroxy-4-methyloxolan-3-yl]ethanone
  参考文献：
  名称：

  Lipase-catalysed deacetylation of botryodiplodin acetate

  摘要：

  Enantioselective deacetylation of alpha-(+/-)-botryodiplodin acetate was successfully accomplished by means of lipase PS to afford (+)-botryodiplodin and alpha-(+)-botryodiplodin acetate with high enantiomeric excesses. Enzyme-mediated transesterification of the acetylated molecule with n-butanol, as well as its hydrolysis in several organic solvents, are also reported. The CD spectra of (+)-botryodiplodin and alpha-(+)-botryodiplodin acetate are also presented. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.02.008

文献信息

• Lipase-catalysed deacetylation of botryodiplodin acetate
  作者：Cristina Forzato、Giada Furlan、Franco Ghelfi、Patrizia Nitti、Giuliana Pitacco、Fabrizio Roncaglia、Ennio Valentin

  DOI：10.1016/j.tetasy.2007.02.008

  日期：2007.3

  Enantioselective deacetylation of alpha-(+/-)-botryodiplodin acetate was successfully accomplished by means of lipase PS to afford (+)-botryodiplodin and alpha-(+)-botryodiplodin acetate with high enantiomeric excesses. Enzyme-mediated transesterification of the acetylated molecule with n-butanol, as well as its hydrolysis in several organic solvents, are also reported. The CD spectra of (+)-botryodiplodin and alpha-(+)-botryodiplodin acetate are also presented. (c) 2007 Elsevier Ltd. All rights reserved.