2-[(6-chloro-2-phenylpyrimidin-4-yl)methylamino]ethanol | 869639-42-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(6-chloro-2-phenylpyrimidin-4-yl)methylamino]ethanol
• 英文别名: 2-[(6-Chloro-2-phenylpyrimidin-4-yl)-methylamino]ethanol
• CAS: 869639-42-9
• 化学式: C₁₃H₁₄ClN₃O
• mdl: MFCD25908021
• 分子量: 263.727
• InChiKey: RWIPGJXQIXETIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  49.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(6-chloro-2-phenylpyrimidin-4-yl)methylamino]ethanol 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 20.0 ℃ 、379.21 kPa 条件下， 反应 15.0h， 以59%的产率得到2-[methyl(2-phenylpyrimidin-4-yl)amino]ethanol
  参考文献：
  名称：

  Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione

  摘要：

  We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKA(y) mice. From the results, novel compounds, 5c and 5g, exhibited considerably more potent biological activity than that of the reference compounds, pioglitazone and rosiglitazone, respectively. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.03.019
• 作为产物：
  描述：

  苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 copper(I) oxide 、 亚硝酸异戊酯 作用下， 反应 27.0h， 生成 2-[(6-chloro-2-phenylpyrimidin-4-yl)methylamino]ethanol
  参考文献：
  名称：

  Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione

  摘要：

  We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKA(y) mice. From the results, novel compounds, 5c and 5g, exhibited considerably more potent biological activity than that of the reference compounds, pioglitazone and rosiglitazone, respectively. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.03.019

文献信息

• Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione
  作者：H LEE、B KIM、J AHN、S KANG、J LEE、J SHIN、S AHN、S LEE、S YOON

  DOI：10.1016/j.ejmech.2005.03.019

  日期：2005.9

  We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKA(y) mice. From the results, novel compounds, 5c and 5g, exhibited considerably more potent biological activity than that of the reference compounds, pioglitazone and rosiglitazone, respectively. (c) 2005 Elsevier SAS. All rights reserved.