2-Hydroxy-3-methoxy-5-(3-pyridinyl)benzaldehyde | 1093118-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Hydroxy-3-methoxy-5-(3-pyridinyl)benzaldehyde
• 英文别名: 2-hydroxy-3-methoxy-5-pyridin-3-ylbenzaldehyde
• CAS: 1093118-29-6
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.235
• InChiKey: RXRLTYDBSJJXMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-3-methoxy-5-(3-pyridinyl)benzaldehyde 、 、 zinc(II) acetate dihydrate 以 乙醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis and two-photon absorption properties of unsymmetrical metallosalophen complexes

  摘要：

  Several new unsymmetrical metallosalphen complexes derived from the condensation of a monoimine and salicylaldehyde in the presence of a transition metal ion as a template have been synthesized and characterized. Their linear and third-order non-linear optical (NLO) properties have been investigated in detail. With different substituted donor or acceptor groups at the 5-position of the salicylidene fragment, these metallosalophen complexes exhibit slightly different two-photon absorption (TPA) cross-section sigma((2)) values. Theoretical calculations based on density functional theory were also carried out to help with the interpretations of the experimental results. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.09.050
• 作为产物：
  描述：

  3-methylimidazole 、 5-溴-2-羟基-3-甲氧基苯甲醛 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 甲苯 为溶剂， 生成 2-Hydroxy-3-methoxy-5-(3-pyridinyl)benzaldehyde
  参考文献：
  名称：

  Synthesis and two-photon absorption properties of unsymmetrical metallosalophen complexes

  摘要：

  Several new unsymmetrical metallosalphen complexes derived from the condensation of a monoimine and salicylaldehyde in the presence of a transition metal ion as a template have been synthesized and characterized. Their linear and third-order non-linear optical (NLO) properties have been investigated in detail. With different substituted donor or acceptor groups at the 5-position of the salicylidene fragment, these metallosalophen complexes exhibit slightly different two-photon absorption (TPA) cross-section sigma((2)) values. Theoretical calculations based on density functional theory were also carried out to help with the interpretations of the experimental results. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.09.050

文献信息

• IRE-1alpha INHIBITORS
  申请人：MannKind Corporation

  公开号：US20140080832A1

  公开（公告）日：2014-03-20

  Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

  直接抑制IRE-1α活性的化合物、前药及其药学上可接受的盐。这些化合物和前药可用于治疗与未折叠蛋白应答相关的疾病，并可作为单一药物或联合治疗的组分。
• IRE-1alpha Inhibitors
  申请人：MannKind Corporation

  公开号：US20160168116A1

  公开（公告）日：2016-06-16

  Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
• US7858666B2
  申请人：——

  公开号：US7858666B2

  公开（公告）日：2010-12-28
• US9241942B2
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  公开号：US9241942B2

  公开（公告）日：2016-01-26
• US9546149B2
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  公开号：US9546149B2

  公开（公告）日：2017-01-17