7-hydroxy-4-methyl-2-oxo-2H-chromene-6-sulfonic acid | 109600-20-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxy-4-methyl-2-oxo-2H-chromene-6-sulfonic acid
• 英文别名: 7-Hydroxy-4-methyl-2-oxo-2H-chromen-6-sulfonsaeure；7-Hydroxy-4-methyl-2-oxochromene-6-sulfonic acid
• CAS: 109600-20-6
• 化学式: C₁₀H₈O₆S
• 分子量: 256.236
• InChiKey: MIUVMONOSRDVQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  羟甲香豆素 在 chlorosulphuric acid 作用下， 生成 7-hydroxy-4-methyl-2-oxo-2H-chromene-6-sulfonyl chloride 、 7-hydroxy-4-methyl-2-oxo-2H-chromene-6-sulfonic acid
  参考文献：
  名称：

  Merchant; Shah, Journal of the Indian Chemical Society, 1957, vol. 34, p. 35,36, 39

  摘要：

  DOI：

文献信息

• METHOD OF ASSAYING LYSOPHOSPHOLIPASE D ACTIVITY
  申请人：Azwell Inc.

  公开号：EP1357126A1

  公开（公告）日：2003-10-29

  The present invention provides a lysophospholipid of the formula (I) wherein R1 and R2 are different from each other and one of them is a saturated or unsaturated fatty acid residue having 8 to 22 carbon atoms, and the other is a hydrogen atom or an acetyl group, and X is a chromophore, a method of assaying a lysophospholipase D activity using the phospholipid as a substrate, a method of screening a substance that inhibits LPLD activity and a reagent and a reagent kit useful for these methods. By the use of the novel lysophospholipid of the present invention as a substrate, a specific and high sensitivity LPLD activity assay becomes attainable. Moreover, by the use of a safe and conveniently detectable chromophore, a number of samples can be assayed rapidly.

  本发明提供了一种溶血磷脂，其式为(I) 其中 R1 和 R2 互不相同，其中一个是具有 8 至 22 个碳原子的饱和或不饱和脂肪酸残基，另一个是氢原子或乙酰基，X 是发色团；一种以该磷脂为底物测定溶血磷脂酶 D 活性的方法；一种筛选抑制 LPLD 活性的物质的方法；以及一种用于这些方法的试剂和试剂盒。使用本发明的新型溶血磷脂作为底物，可以实现特异性和高灵敏度的 LPLD 活性检测。此外，通过使用一种安全且方便检测的发色团，可以快速检测大量样品。
• Method of assaying iysophospholipase d activity
  申请人：——

  公开号：US20040053893A1

  公开（公告）日：2004-03-18

  The present invention provides a lysophospholipid of the formula (I) 1 wherein R 1 and R 2 are different from each other and one of them is a saturated or unsaturated fatty acid residue having 8 to 22 carbon atoms, and the other is a hydrogen atom or an acetyl group, and X is a chromophore, a method of assaying a lysophospholipase D activity using the phospholipid as a substrate, a method of screening a substance that inhibits LPLD activity and a reagent and a reagent kit useful for these methods. By the use of the novel lysophospholipid of the present invention as a substrate, a specific and high sensitivity LPLD activity assay becomes attainable. Moreover, by the use of a safe and conveniently detectable chromophore, a number of samples can be assayed rapidly.

  本发明提供了一种式 (I) 的溶血磷脂 1 其中 R 1 和 R 2 其中一个是具有 8 至 22 个碳原子的饱和或不饱和脂肪酸残基，另一个是氢原子或乙酰基，X 是发色团；以该磷脂为底物测定溶血磷脂酶 D 活性的方法；筛选抑制 LPLD 活性的物质的方法；以及用于这些方法的试剂和试剂盒。使用本发明的新型溶血磷脂作为底物，可以实现特异性和高灵敏度的 LPLD 活性检测。此外，通过使用一种安全且方便检测的发色团，可以快速检测大量样品。
• US5011964A
  申请人：——

  公开号：US5011964A

  公开（公告）日：1991-04-30
• Merchant; Shah, Journal of the Indian Chemical Society, 1957, vol. 34, p. 35,36, 39
  作者：Merchant、Shah

  DOI：——

  日期：——