5-ethyl-2,4-dimethoxy-6-methyl-pyrimidine | 114426-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-ethyl-2,4-dimethoxy-6-methyl-pyrimidine
• 英文别名: 5-Aethyl-2,4-dimethoxy-6-methyl-pyrimidin；5-Ethyl-2,4-dimethoxy-6-methylpyrimidine
• CAS: 114426-11-8
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: FRWCHUMRVZQCLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.24
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  5-ethyl-2-ethylmercapto-6-methyl-3H-pyrimidin-4-one 在 甲醇 、 水 、 氯 、 三氯氧磷 作用下， 生成 5-ethyl-2,4-dimethoxy-6-methyl-pyrimidine
  参考文献：
  名称：

  Chi; Ling, Scientia Sinica (English Edition), 1957, vol. 6, p. 633,637

  摘要：

  DOI：

文献信息

• Chi; Chin, 1938, vol. 5, p. 19
  作者：Chi、Chin

  DOI：——

  日期：——
• SUBSTITUTED PYRAZOLOPYRIMIDINES AND SUBSTITUTED PURINES AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS
  申请人：KSQ Therapeutics Inc.

  公开号：US20210115049A1

  公开（公告）日：2021-04-22

  The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein X 1 , X 2 , X 11 , X 12 , R 1 , R 3 , R 5 , R 5′ , R 6 , and R 7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.