1,6-Bis-(4-ethinyl-phenoxy)-hexan | 96172-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,6-Bis-(4-ethinyl-phenoxy)-hexan
• 英文别名: 1,6-bis(4-ethynylphenoxy)hexane；1-Ethynyl-4-[6-(4-ethynylphenoxy)hexoxy]benzene
• CAS: 96172-86-0
• 化学式: C₂₂H₂₂O₂
• 分子量: 318.415
• InChiKey: KXLFJIBTIMYGAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-碘-2-((2-吡啶基)乙炔基)苯 、 1,6-Bis-(4-ethinyl-phenoxy)-hexan 在 copper(l) iodide 、 四(三苯基膦)钯 、 正丁胺 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 6.0h， 以38%的产率得到1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane
  参考文献：
  名称：

  Synthesis and biological evaluation of novel symmetry bis-enediynes

  摘要：

  A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50) = 0.04 mu M) and HL-60 (GI(50) = 0.09 mu M) Cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.005
• 作为产物：
  描述：

  1,1'-<1,6-hexanediylbis(oxy-4,1-phenylene)>bisethanone 生成 1,6-Bis-(4-ethinyl-phenoxy)-hexan
  参考文献：
  名称：

  Oligomers and Polymers Containing Triple Bonds. III. Derivatives of α,ω-Bis(4-ethynylphenoxy)alkane

  摘要：

  DOI：

  10.1246/bcsj.37.919

文献信息

• Two-component supramolecular metallogels with the presence of Pt–Pt metal–metal interactions
  作者：Zongchun Gao、Peter A. Korevaar、Ruolei Zhong、Zehong Wu、Feng Wang

  DOI：10.1039/c8cc05575k

  日期：——

  Two-component supramolecular metallogels have been successfully constructed with the involvement of heteromeric Pt(II)⋯Pt(II) metal–metal interactions, which display low-energy emissions in the near-infrared region. We demonstrate and rationalize how the gel stability can be increased by modulating the gelation solvent as well as the crosslinking unit.

  借助异聚体Pt（II）⋯Pt（II）金属与金属的相互作用，成功地构建了两组分超分子金属分子，在近红外区域显示出低能发射。我们证明并合理化如何通过调节凝胶化溶剂以及交联单元来提高凝胶稳定性。
• Synthesis of acetylene-terminated .alpha.,.omega.-bisphenoxy alkanes
  作者：Stephan A. Babirad、William A. Feld

  DOI：10.1021/je00055a040

  日期：1989.1
• BABIRAD, STEPHEN A.;FELD, WILLIAM A., J. CHEM. AND ENG. DATA, 34,(1989) N, C. 140-141
  作者：BABIRAD, STEPHEN A.、FELD, WILLIAM A.

  DOI：——

  日期：——
• Synthesis and biological evaluation of novel symmetry bis-enediynes
  作者：Kuo-Feng Tseng、Chi-Fong Lin、Yu-Hsiang Lo、Yi-Ling Hu、Li-Yi Chen、Sheng-Huei Yang、Shinne-Ren Lin、Long-Sen Chang、Ming-Jung Wu

  DOI：10.1016/j.ejmech.2008.03.005

  日期：2009.1

  A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50) = 0.04 mu M) and HL-60 (GI(50) = 0.09 mu M) Cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. (C) 2008 Elsevier Ltd. All rights reserved.
• Oligomers and Polymers Containing Triple Bonds. III. Derivatives of α,ω-Bis(4-ethynylphenoxy)alkane
  作者：Hisaya Tani、Ken Murayama、Fumio Toda

  DOI：10.1246/bcsj.37.919

  日期：1964.7