benzoylsulfanyl-acetyl chloride | 23094-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoylsulfanyl-acetyl chloride
• 英文别名: S-(2-chloro-2-oxoethyl) benzenecarbothioate
• CAS: 23094-02-2
• 化学式: C₉H₇ClO₂S
• 分子量: 214.672
• InChiKey: ZWDAFYVBHZYYJI-UHFFFAOYSA-N

物化性质

• 沸点：
  283.1±32.0 °C(Predicted)
• 密度：
  1.342±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  59.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzoylsulfanyl-acetyl chloride 、 L-硫代脯氨酸 生成 (4R)-3-(mercaptoacetyl)-4-thiazolidinecarboxylic acid
  参考文献：
  名称：

  New sulfhydryl compounds with potent antihypertensive activities.

  摘要：

  合成了(4R)-3-(巯基)-4-噻唑烷羧酸(III)，并在体外和体内检测了它们对血管紧张素转换酶(ACE)的抑制活性。 (4R)-3-[(2S)-3-巯基-2-甲基丙酰]-4-噻唑烷甲酸(4a)是衍生物中最有效的口服活性ACE抑制剂，其活性与(2S)几乎相同)-1-[(2S)-3-巯基-2-甲基丙酰基]脯氨酸(8)。

  DOI：

  10.1248/cpb.26.1333
• 作为产物：
  描述：

  苯甲酰巯基乙酸 在 草酰氯 作用下， 生成 benzoylsulfanyl-acetyl chloride
  参考文献：
  名称：

  Jia, F.; Liu, B. L.; Liu, Z. H., Journal of labelled compounds and radiopharmaceuticals, 2001, vol. 44, p. S547 - S549

  摘要：

  DOI：

文献信息

• Thiol compounds. III. Synthesis and antihypertensive activity of mercaptoacylamino acids.
  作者：MASAYUKI OYA、EISHIN KATO、JUNZOH MATSUMOTO、YOICHI KAWASHIMA、JUNICHI IWAO

  DOI：10.1248/cpb.29.1203

  日期：——

  A series of mercaptoacylamino acids containing tyrosine, dopa and α-methyldopa moieties is reported, and the structure-activity relationships are discussed. These compounds were tested for antihypertensive activity, and some of the compounds exhibited inhibitory activity against angiotensin I-converting enzyme. N-(2-Mercaptopropanoyl)-L-tyrosine-b (6b) was found to be 5 times more potent than N-(2-mercaptopropanoyl)-L-phenylalanine-a (Ia).

  报道了一系列含有酪氨酸、多巴和α-甲基多巴结构的巯基乙酰氨基酸，并讨论了其结构-活性关系。这些化合物被测试了抗高血压活性，其中一些化合物对血管紧张素I转化酶表现出抑制活性。N-(2-巯基丙酰)-L-酪氨酸-b (6b) 的效力被发现是N-(2-巯基丙酰)-L-苯丙氨酸-a (Ia) 的5倍。
• Synthesis and antihypertensive activity of N-(mercaptoacyl)-thiazolidinecarboxylic acids.
  作者：MASAYUKI OYA、TOSHIO BABA、EISHIN KATO、YOICHI KAWASHIMA、TOSHIO WATANABE

  DOI：10.1248/cpb.30.440

  日期：——

  The synthesis and antihypertensive activity of a new series of N-(mercaptoacyl)-thiazolidinecarboxylic acids (VIIa-d) are described. Antihypertensive activity was evaluated in terms of angiotensin I-converting enzyme (ACE) inhibitory activity. The activities of these compounds were compared with that of (2S)-1-[(2S)-3-mercapto-2-methylpropanoyl] proline, SQ 14225, and many of them were found to be relatively potent inhibitors of ACE. The most potent was (4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidinecarboxylic acid (62). Structure-activity relationships among the thiazolidines and some related compounds are discussed.

  报道了一系列新型N-(巯基乙酰基)-噻唑烷羧酸(VIIa-d)的合成及其抗高血压活性。抗高血压活性通过血管紧张素I转化酶(ACE)抑制活性来评估。这些化合物的活性与(2S)-1-[(2S)-3-巯基-2-甲基丙酰基]脯氨酸(SQ 14225)进行了比较，发现其中许多化合物是相对强效的ACE抑制剂。其中最有效的是(4R)-2-(2-羟基苯基)-3-(3-巯基丙酰基)-4-噻唑烷羧酸(62)。讨论了噻唑烷及其相关化合物的结构-活性关系。
• RESIST POLYMER, RESIST COMPOSITION, PROCESS FOR PATTERN FORMATION, AND STARTING COMPOUNDS FOR PRODUCTION OF THE RESIST POLYMER
  申请人：Momose Hikaru

  公开号：US20090198065A1

  公开（公告）日：2009-08-06

  To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like. In formulas (1) and (2), n represents an integer of 2 to 24; J represents a single bond or a divalent hydrocarbon group which may have a substituent/heteroatom when n=2, or represents an n-valent hydrocarbon group which may have a substituent/heteroatom when n≧3; E represents a residue of a polymerization terminator, a chain transfer agent or a polymerization initiator; K 1 and K 2 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene, arylene, a divalent thiazoline ring, a divalent oxazoline ring and a divalent imidazoline ring; L 1 and L 2 each represent at least one selected from —C(O)O—, —C(O)— and —OC(O)—; M 1 , M 2 and M 3 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene and arylene; Y, Y 1 and Y 2 each represent an acid-decomposable linkage; k1, k2, l1, l2, m1, m2, and m3 each represent 0 or 1; and R 1 represents H or a methyl group.

  提供一种抗蚀聚合物，其由一个具有结构式（1）或（2）所表示的酸分解单元作为结构单元，能够在DUV准分子激光微影或类似工艺中表现出小的线边粗糙度并产生少量缺陷。在式（1）和（2）中，n表示2至24的整数；J表示单键或二价碳氢基团，当n=2时可以具有取代基/杂原子，或者当n≥3时可以表示n价碳氢基团，可以具有取代基/杂原子；E表示聚合终止剂、链转移剂或聚合引发剂的残基；K1和K2分别表示至少选择自烷基、环烷基、氧烷基、芳烃、二价噻唑环、二价噁唑环和二价咪唑环中的至少一种；L1和L2分别表示至少选择自—C（O）O—、—C（O）—和—OC（O）—中的至少一种；M1、M2和M3分别表示至少选择自烷基、环烷基、氧烷基和芳烃中的至少一种；Y、Y1和Y2分别表示酸分解键；k1、k2、l1、l2、m1、m2和m3分别表示0或1；R1表示H或甲基基团。
• Alkylamide derivatives with H2-receptor antagonistic and cytoprotective action
  申请人：FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.

  公开号：EP0214823A2

  公开（公告）日：1987-03-18

  Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H2-receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.

  式的烷基酰胺衍生物、 这些化合物具有很强的抗溃疡作用，这取决于组胺 H2 受体的拮抗作用和对胃黏膜的细胞保护作用。
• Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
  申请人：Dupont Pharmaceuticals Company

  公开号：EP0995761A2

  公开（公告）日：2000-04-26

  This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to the methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.

  本发明提供了新型放射性药物，它们是含有碳环或杂环环系统的放射性标记环状化合物，可作为血小板糖蛋白 IIb/IIIa 复合物的拮抗剂；提供了将所述放射性药物用作诊断动脉和静脉血栓的成像剂的方法；提供了制备所述放射性药物的新型试剂；以及提供了包含所述试剂的试剂盒。