3,4-dihydroxy-17,17-ethylenedioxy-1,3,5(10)-estratrien-6-one diacetate | 360771-91-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,4-dihydroxy-17,17-ethylenedioxy-1,3,5(10)-estratrien-6-one diacetate
• CAS: 360771-91-1
• 化学式: C₂₄H₂₈O₇
• 分子量: 428.482
• InChiKey: JXGFPKIMYYSOQU-VGHKVXAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  31.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  88.13
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  3,4-dihydroxy-17,17-ethylenedioxy-1,3,5(10)-estratrien-6-one diacetate 在 吡啶 、 碳酸氢钠 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 13.0h， 生成 3-苄氧基-4-羟基-17,17-亚乙二氧基-1,3,5(10)-雌三烯-6-酮乙酸酯
  参考文献：
  名称：

  Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen

  摘要：

  The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the B-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions. (C) 2001 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(00)00236-1
• 作为产物：
  描述：

  乙二醇 、 [(8R,9S,13S,14S)-4-acetyloxy-13-methyl-6,17-dioxo-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-yl] acetate 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 5.0h， 以67%的产率得到3,4-dihydroxy-17,17-ethylenedioxy-1,3,5(10)-estratrien-6-one diacetate
  参考文献：
  名称：

  Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen

  摘要：

  The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the B-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions. (C) 2001 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(00)00236-1