2-propyl-4-phenylphenol | 194792-75-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-propyl-4-phenylphenol
• 英文别名: 4-hydroxy-3-propyl-biphenyl；4-phenyl-2-propylphenol
• CAS: 194792-75-1
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: UIFYLOYBNHJKDV-UHFFFAOYSA-N

物化性质

• 沸点：
  332.9±11.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-propyl-4-phenylphenol 在 氨 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

  摘要：

  A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/s0960-894x(03)00785-6
• 作为产物：
  描述：

  1-烯丙氧基-4-氯甲基-苯 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 邻二氯苯 为溶剂， 生成 2-propyl-4-phenylphenol
  参考文献：
  名称：

  Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

  摘要：

  A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/s0960-894x(03)00785-6

文献信息

• Hypervalent iodine oxidation of phenol derivatives using a catalytic amount of 4-iodophenoxyacetic acid and Oxone® as a co-oxidant
  作者：Takayuki Yakura、Masanori Omoto、Yû Yamauchi、Yuan Tian、Ayaka Ozono

  DOI：10.1016/j.tet.2010.04.124

  日期：2010.7

  Reaction of p-substituted phenols 2 with a catalytic amount of 4-iodophenoxyacetic acid (1) and Oxone® as a co-oxidant in tetrahydrofuran (THF) or 1,4-dioxane–water gave the corresponding p-quinols 3 in excellent yields. Reaction of p-dialkoxyarenes 4 in 2,2,2-trifluoroethanol–water gave the corresponding p-quinones 5 in excellent yield without purification. These reactions provide efficient and practical

  的反应p取代的酚2用4- iodophenoxyacetic酸（催化剂量1）过硫酸氢钾®如四氢呋喃（THF）的共氧化剂或1,4-二恶烷-水，得到相应的p -quinols 3以优良产率。的反应p -dialkoxyarenes 4在2,2,2-三氟乙醇-水，得到相应的p -quinones 5的优良率，无需纯化。这些反应为由对位取代的苯酚和对位苯甲酸制备对苯二酚和对苯醌提供了有效而实用的方法。-二烷氧基芳烃。该醌合成用于德国小att Blattella germanica的性信息素blattellaquinone（13）的合成。
• [EN] SYNTHESIS OF TERPHENYL COMPOUNDS<br/>[FR] SYNTHÈSE DE COMPOSÉS TERPHÉNYLE
  申请人：VECTUS BIOSYSTEMS LTD

  公开号：WO2017049343A1

  公开（公告）日：2017-03-30

  The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I or intermediates thereof.

  本发明涉及一种合成三苯基化合物的新方法，特别是用于合成化合物I的新方法或其中间体的方法。
• Disubstituted biphenyloxazolines
  申请人：Bayer Aktiengesellschaft

  公开号：US06410581B1

  公开（公告）日：2002-06-25

  The present invention relates to novel biphenyloxazolines of the formula (I) in which X1, X2, X3, R1, R2 and R3 are each as defined in the description, to processes for their preparation and to the use of the biphenyloxazolines for controlling animal pests.

  本发明涉及公式（I）中的新型联苯氧唑啉，其中X1、X2、X3、R1、R2和R3的定义如说明书所述，以及它们的制备过程和用于控制动物害虫的联苯氧唑啉的用途。
• DISUBSTITUTED BIPHENYLOXAZOLINES
  申请人：——

  公开号：US20020086892A1

  公开（公告）日：2002-07-04

  The present invention relates to novel biphenyloxazolines of the formula (I) 1 in which X 1 , X 2 , X 3 , R 1 , R 2 and R 3 are each as defined in the description, to processes for their preparation and to the use of the biphenyloxazolines for controlling animal pests.

  本发明涉及式(I)1的新型联苯氧唑化合物，其中X1、X2、X3、R1、R2和R3的定义详见说明书，以及其制备方法和用于控制动物害虫的应用。
• PROCESS FOR PRODUCING ISOCYANATES
  申请人：Shinohata Masaaki

  公开号：US20100029981A1

  公开（公告）日：2010-02-04

  An object of the present invention is to provide a process that enables isocyanates to be stably produced over a long period of time at high yield without encountering various problems as found in the prior art when producing isocyanates without using phosgene. The present invention discloses a process for producing an isocyanate, comprising the steps of: reacting a carbamic acid ester and an aromatic hydroxy compound to obtain an aryl carbamate having a group derived from the aromatic hydroxy compound; and subjecting the aryl carbamate to a decomposition reaction, wherein the aromatic hydroxy compound is an aromatic hydroxy compound which is represented by the following formula (1) and which has a substituent R 1 at least one ortho position of a hydroxyl group: (wherein ring A represents an aromatic hydrocarbon ring in a form of a single or multiple rings which may have a substitute and which have 6 to 20 carbon atoms; R 1 represents a group other than a hydrogen atom in a form of an aliphatic alkyl group having 1 to 20 carbon atoms, an aliphatic alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms or an aralkyloxy group having 7 to 20 carbon atoms, the group containing an atom selected from a carbon atom, an oxygen atom and a nitrogen atom; and R 1 may bond with A to form a ring structure).

  本发明的目的是提供一种过程，使得在不使用光气的情况下，能够稳定地高产长时间生产异氰酸酯，而不会遇到生产异氰酸酯时在先前技术中发现的各种问题。本发明公开了一种生产异氰酸酯的方法，包括以下步骤：反应一个氨基甲酸酯和一个芳香羟基化合物以获得含有源自芳香羟基化合物的基团的芳基氨基甲酸酯；并将芳基氨基甲酸酯进行分解反应，其中芳香羟基化合物是由以下式（1）表示并且在羟基位置的至少一个邻位上具有取代基R1的芳香羟基化合物：（其中，环A表示一个具有单个或多个环，并且可能具有取代基的芳香烃环，其具有6至20个碳原子；R1表示除氢原子外的基团，以具有1至20个碳原子的脂肪基烷基团，具有1至20个碳原子的脂肪基烷氧基团，具有6至20个碳原子的芳基团，具有6至20个碳原子的芳氧基团，具有7至20个碳原子的芳基烷基团或具有7至20个碳原子的芳基烷氧基团，该基团含有从碳原子、氧原子和氮原子中选择的原子；并且R1可以与A结合形成一个环状结构）。