(Pyrrolidin-1-yl)acrylic acid ethyl ester | 1027618-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (Pyrrolidin-1-yl)acrylic acid ethyl ester
• 英文别名: Ethyl 2-pyrrolidin-1-ylprop-2-enoate
• CAS: 1027618-39-8
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: HEFKWTYVBGTWKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙炔酰胺 、 (Pyrrolidin-1-yl)acrylic acid ethyl ester 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 60.0h， 以22.5 mg的产率得到反-4-溴-Β-硝基苯乙烯
  参考文献：
  名称：

  An annulation method for the synthesis of alkyl-substituted 6-carbomethoxy-2-pyridones

  摘要：

  A protocol for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones was devised. Key steps include a Mannich reaction, acylation of a tosylamine, and a PPh3/TiCl4-promoted intramolecular Reformatsky-type reaction with a thioester as the electrophile. The latter process typically afforded a vinylogous thiocarbamate via elimination of water rather than the Dieckmann-type product which would have resulted from elimination of the thiol. However, the Dieckmann-type ketone product was obtained in one instance. Subsequent elimination of the tosyl group and desulfurization completed the pyridone synthesis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.006
• 作为产物：
  描述：

  四氢吡咯 、 丙酮酸乙酯 以 苯 为溶剂， 反应 5.0h， 生成 (Pyrrolidin-1-yl)acrylic acid ethyl ester
  参考文献：
  名称：

  An annulation method for the synthesis of alkyl-substituted 6-carbomethoxy-2-pyridones

  摘要：

  A protocol for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones was devised. Key steps include a Mannich reaction, acylation of a tosylamine, and a PPh3/TiCl4-promoted intramolecular Reformatsky-type reaction with a thioester as the electrophile. The latter process typically afforded a vinylogous thiocarbamate via elimination of water rather than the Dieckmann-type product which would have resulted from elimination of the thiol. However, the Dieckmann-type ketone product was obtained in one instance. Subsequent elimination of the tosyl group and desulfurization completed the pyridone synthesis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.006

文献信息

• BIORESORBIERBARE OBERFLÄCHENBESCHICHTUNG ZUR DEGRADATIONSVERZÖGERUNG
  申请人：Drei Lilien PVG GmbH & Co. KG

  公开号：EP3648806A1

  公开（公告）日：2020-05-13
• BIORESORBABLE SURFACE COATING FOR DELAYING DEGRADATION
  申请人：Drei Lilien PVG GmbH & Co. KG

  公开号：US20200171214A1

  公开（公告）日：2020-06-04

  The present invention relates to a biodegradable surface coating for inhibiting/delaying erosion/corrosion or degradation of solid materials for medical applications and their integration into cell assemblies.