2-(benzyloxy)methyl-3-dodecyloxy-2-methylpropan-1-ol | 1020110-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzyloxy)methyl-3-dodecyloxy-2-methylpropan-1-ol
• 英文别名: 2-(Dodecoxymethyl)-2-methyl-3-phenylmethoxypropan-1-ol；2-(dodecoxymethyl)-2-methyl-3-phenylmethoxypropan-1-ol
• CAS: 1020110-27-3
• 化学式: C₂₄H₄₂O₃
• 分子量: 378.596
• InChiKey: JCQSALNDSHDKPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(benzyloxy)methyl-3-dodecyloxy-2-methylpropan-1-ol 、 甲磺酸,2-[2-(2-甲氧基乙氧基)乙氧基]乙醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以73%的产率得到1-((2-((2-(2-(2-甲氧基乙氧基)乙氧基)乙氧基)甲基)-3-(十二烷氧基)-2-甲基丙氧基)甲基)苯
  参考文献：
  名称：

  Synthesis of a pH-independent bifurcated amphiphile

  摘要：

  An efficient synthetic method for preparing bifurcated amphiphiles has been developed such that the functionality for attachment is located at the interface between the lipophilic and hydrophilic side chains. Attachment of the amphiphile to the repeat units of polymeric substrates enables the rapid preparation of amphiphilic homopolymers. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.132
• 作为产物：
  描述：

  5-(dodecyloxy)methyl-5-methyl-2-phenyl-1,3-dioxane 在 二异丁基氢化铝 作用下， 以 Petroleum ether 为溶剂， 反应 12.0h， 生成 2-(benzyloxy)methyl-3-dodecyloxy-2-methylpropan-1-ol
  参考文献：
  名称：

  Synthesis of a pH-independent bifurcated amphiphile

  摘要：

  An efficient synthetic method for preparing bifurcated amphiphiles has been developed such that the functionality for attachment is located at the interface between the lipophilic and hydrophilic side chains. Attachment of the amphiphile to the repeat units of polymeric substrates enables the rapid preparation of amphiphilic homopolymers. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.132

文献信息

• Synthesis of a pH-independent bifurcated amphiphile
  作者：Kaitlin A. Willham、Boyd A. Laurent、Scott M. Grayson

  DOI：10.1016/j.tetlet.2008.01.132

  日期：2008.3

  An efficient synthetic method for preparing bifurcated amphiphiles has been developed such that the functionality for attachment is located at the interface between the lipophilic and hydrophilic side chains. Attachment of the amphiphile to the repeat units of polymeric substrates enables the rapid preparation of amphiphilic homopolymers. (C) 2008 Elsevier Ltd. All rights reserved.