3-amino-6-(4-methylphenyl)thieno[2,3-b]pyridine-2-carbonitrile | 342397-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-amino-6-(4-methylphenyl)thieno[2,3-b]pyridine-2-carbonitrile
• CAS: 342397-06-2
• 化学式: C₁₅H₁₁N₃S
• 分子量: 265.338
• InChiKey: CRXCTUFUOUPKJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-amino-6-(4-methylphenyl)thieno[2,3-b]pyridine-2-carbonitrile 、 硫代异氰酸苯酯 在 吡啶 、 盐酸 作用下， 以 水 为溶剂， 反应 48.0h， 以91%的产率得到4-imino-7-(4-methylphenyl)-3-phenyl-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]-pyrimidine
  参考文献：
  名称：

  Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles

  摘要：

  In the present study, 3-aminothieno[2,3-b] pyridines, pyrido[3',2' :4,5] thieno[3,2-d]pyrimidinones, and pyrido[3',2' : 4,5]thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halogen-containing compounds. The structures of all the newly synthesized heterocyclic compounds were established by considering elemental analysis and spectral data.[GRAPHICS].

  DOI：

  10.1080/17415993.2012.661734
• 作为产物：
  描述：

  2-thioxo-6-(p-tolyl)-1,2-dihydropyridine-3-carbonitrile 在 sodium methylate 、 sodium ethanolate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 3.25h， 生成 3-amino-6-(4-methylphenyl)thieno[2,3-b]pyridine-2-carbonitrile
  参考文献：
  名称：

  Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles

  摘要：

  In the present study, 3-aminothieno[2,3-b] pyridines, pyrido[3',2' :4,5] thieno[3,2-d]pyrimidinones, and pyrido[3',2' : 4,5]thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halogen-containing compounds. The structures of all the newly synthesized heterocyclic compounds were established by considering elemental analysis and spectral data.[GRAPHICS].

  DOI：

  10.1080/17415993.2012.661734

文献信息

• ABCA-1 elevating compounds
  申请人：——

  公开号：US20030220356A1

  公开（公告）日：2003-11-27

  The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.

  本发明提供了一种能够提高ABCA-1基因细胞表达的化合物，促进胆固醇从细胞中流出并增加哺乳动物（尤其是人类）血浆中的高密度脂蛋白水平。这些化合物可用于治疗冠心病。
• COMPOUNDS FOR INCREASING ABCA-1 EXPRESSION USEFUL FOR TREATING CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1513534A2

  公开（公告）日：2005-03-16
• US6900219B2
  申请人：——

  公开号：US6900219B2

  公开（公告）日：2005-05-31
• [EN] ABCA-1 ELEVATING COMPOUNDS<br/>[FR] COMPOSES PERMETTANT D'AUGMENTER L'ABCA-1
  申请人：CV THERAPEUTICS INC

  公开号：WO2003084544A2

  公开（公告）日：2003-10-16

  The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease and atherosclerosis.
• Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles
  作者：Fawzy A. Attaby、Ahmed H. El-Ghandour、Abdelwahed R. Sayed、Ashraf A. El Bassuony、Ahmed A.M. El-Reedy

  DOI：10.1080/17415993.2012.661734

  日期：2012.4.1

  In the present study, 3-aminothieno[2,3-b] pyridines, pyrido[3',2' :4,5] thieno[3,2-d]pyrimidinones, and pyrido[3',2' : 4,5]thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halogen-containing compounds. The structures of all the newly synthesized heterocyclic compounds were established by considering elemental analysis and spectral data.[GRAPHICS].