ω-Formylamino-oenanthsaeure | 1120-14-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ω-Formylamino-oenanthsaeure
• 英文别名: 7-(Formylamino)heptanoic acid；7-formamidoheptanoic acid
• CAS: 1120-14-5
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: BQWAOBSCCHSACX-UHFFFAOYSA-N

物化性质

• 熔点：
  96.5-98.0 °C
• 沸点：
  403.1±28.0 °C(Predicted)
• 密度：
  1.073±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲酸 、 7-氨基庚酸 生成 ω-Formylamino-oenanthsaeure
  参考文献：
  名称：

  Velichko,F.K. et al., Journal of applied chemistry of the USSR, 1965, vol. 38, p. 142 - 147

  摘要：

  DOI：

文献信息

• COOPERATIVE CONVEYANCE OF BASIC ACTIVE PRINCIPLES BY AMPHIPHILIC ACID MOLECULES
  申请人：Bize Cécile

  公开号：US20120214756A1

  公开（公告）日：2012-08-23

  The present invention relates to an intermolecular association complex of an amphiphilic carrier and an active principle G, having the following general formula (I), as well as to the compositions containing same, to the uses thereof, particularly as a drug, and to the method for preparing same.

  本发明涉及一种两亲性载体和活性成分G的分子间缔合物，具有以下通式（I），以及含有该分子间缔合物的组合物，其用途，特别是作为药物，以及其制备方法。
• A composition for increasing the anti-cancer activity of an anti-cancer compound
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0180188A2

  公开（公告）日：1986-05-07

  A composition for increasing the anti-cancer activity of an anti-cancer compound selected from among 5-fluorouracil and a compound capable of producing 5-fluorouracil in vivo, the composition comprising an effective amount of a pyridine derivative represented by the formula wherein R1 is hydroxy or acyloxy, R2 and R4 are each hydrogen, halogen, amino, carboxyl, carbamoyl, cyano, nitro, lower alkyl, lower alkenyl or lower alkoxycarbonyl, R3 and R are each hydrogen, hydroxy or acyloxy; when at least one of R1, R3 and R5 is hydroxy, the structure of 1-position on the pyridine rina can be duetothe due to the keto-enol tautomerism, said hydrogen attached to nitrogen being optionally substituted with a substituent selected from the group consisting of lower alkyl, tetrahydrofuranyl, tetrahydropyranyl, lower alkoxy-lower alkyl, phthalidyl, carbamoyl, lower alkoxycarbonyl-lower alkylcarbamoyl, phenyl-lower alkoxy-lower alkyl, phenylcarbamoyl which may have a substituent on the phenyl ring, lower alkylcarbamoyl, carboxy-lower alkylcarbamoyl, lower alkylthio-lower alkyl and lower alkenyl, provided that the compound having the following formula is excluded, wherein a is hydrogen, lower alkyl, tetrahydrofuranyl, tetrahydropyranyl, lower alkoxy-lower alkyl, lower alkylcarbamoyl, lower alkylthio-lower alkyl or lower alkenyl.

  一种提高选自5-氟尿嘧啶和一种能在体内产生5-氟尿嘧啶的化合物的抗癌活性的组合物，该组合物包括有效量的由式表示的吡啶衍生物 其中 R1 是羟基或酰氧基，R2 和 R4 分别是氢、卤素、氨基、羧基、氨基甲酰基、氰基、硝基、低级烷基、低级烯基或低级烷氧基羰基，R3 和 R 分别是氢、羟基或酰氧基；当 R1、R3 和 R5 中至少有一个是羟基时，吡啶里纳上 1 位的结构可以是 当 R1、R3 和 R5 中至少有一个是羟基时，吡啶里纳上 1 位的结构可以是酮烯醇同分异构，所述连接到氮上的氢可选择被选自低烷基、四氢呋喃基、四氢吡喃基、低烷氧基低烷基、邻苯二甲酰基、氨基甲酰基、低烷氧基羰基低烷基氨基甲酰基组成的取代基取代、苯基-低级烷氧基-低级烷基、苯基氨基甲酰基（苯基环上可能有取代基）、低级烷基氨基甲酰基、羧基-低级烷基氨基甲酰基、低级烷硫基-低级烷基和低级烯基，但具有下式的化合物除外、 其中 a 为氢、低级烷基、四氢呋喃基、四氢呋喃基、低级烷氧基低级烷基、低级烷基氨基甲酰基、低级烷硫基低级烷基或低级烯基。
• 5-flurorouracil derivatives
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0247381A2

  公开（公告）日：1987-12-02

  This invention relates to a 5-fluorouracil derivative represented by the formula wherein RY is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R1 and R2 are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group RxOCO- on the phenyl ring, or a group -(A)nB, R" being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R is a hydrogen atom or acyl group, R2 is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition.

  本发明涉及一种 5-氟尿嘧啶衍生物，其式如下 其中 RY 是氢原子或特定酰基，Z 是苯基-低级烷氧基-低级烷基，噻吩基-低级烷基，可选择在噻吩基环上被卤素原子取代，或一个基团 其中 R1 和 R2 分别是氢原子、特定的酰基、苯基环上带有基团 RxOCO- 的苯基-低级烷基或基团-(A)nB，R "是特定的有机基团，A 是低级亚烷基，n 是 0 或 1、和 B 是 5 或 6 元不饱和杂环基团，具有 1 至 4 个选自氮、氧和硫的杂原子，并可选具有苯环、萘环或吡啶环，但当 R 是氢原子或酰基时，R2 不是氢原子或酰基；制备上述物质的工艺；包含有效量上述物质的抗癌组合物；以及使用上述物质制备抗癌组合物。
• PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES
  申请人：OTSUKA PHARMACEUTICAL FACTORY, INC.

  公开号：EP1081149A1

  公开（公告）日：2001-03-07

  The present invention provides pyrazolo[1,5-a]pyrimidine derivatives represented by the formula (1) wherein R1 represents lower alkyl or the like; one of R2 and R3 represents hydrogen and the other represents phenyl having lower alkoxy or the like, and R4 is hydrogen, carboxyl, lower alkoxy-carbonyl or the like. The derivatives of the invention have pharmacological effects such as analgesic action, inhibitory effect on nitrogen monoxide synthetase and the like and are useful as analgesics. The derivatives of the invention are also useful as therapeutic or prophylactic agents for septicemia, endotoxin shock, chronic articular rheumatism, etc.

  本发明提供由式（1）表示的吡唑并[1,5-a]嘧啶衍生物 其中 R1 代表低级烷基或类似物；R2 和 R3 中的一个代表氢，另一个代表具有低级烷氧基或类似物的苯基，R4 是氢、羧基、低级烷氧基-羰基或类似物。本发明的衍生物具有镇痛作用、一氧化氮合成酶抑制作用等药理作用，可用作镇痛剂。本发明的衍生物还可作为治疗或预防败血症、内毒素休克、慢性关节风湿病等的药物。
• 5-Fluorouracil derivatives
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0323441B1

  公开（公告）日：1996-04-24