1-methanesulfonate 3-[(4-methoxyphenyl)methoxy]-1-propanol | 352557-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methanesulfonate 3-[(4-methoxyphenyl)methoxy]-1-propanol
• 英文别名: Methanesulfonic acid 3-(4-methoxy-benzyloxy)-propyl ester；3-[(4-Methoxyphenyl)methoxy]propyl methanesulfonate
• CAS: 352557-00-7
• 化学式: C₁₂H₁₈O₅S
• 分子量: 274.338
• InChiKey: YYJOAEAFPDFCDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-methanesulfonate 3-[(4-methoxyphenyl)methoxy]-1-propanol 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以98%的产率得到1-[(3-iodopropoxy)methyl]-4-methoxybenzene
  参考文献：
  名称：

  Studies on the synthesis of (±)-pathylactone A, a nor-sesquiterpene lactone isolated from marine sources

  摘要：

  An approach to the synthesis of a highly substituted carbon skeleton exhibited by some unusual nor-sesquiterpenes isolated from marine sources, is described. Our strategy was applied for the total synthesis of pathylactone A, which has now been prepared by an unambiguous route and found to be different from the natural product. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00058-3
• 作为产物：
  描述：

  4-甲氧基氯苄 在 4-二甲氨基吡啶 、 四丁基碘化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 1-methanesulfonate 3-[(4-methoxyphenyl)methoxy]-1-propanol
  参考文献：
  名称：

  Studies on the synthesis of (±)-pathylactone A, a nor-sesquiterpene lactone isolated from marine sources

  摘要：

  An approach to the synthesis of a highly substituted carbon skeleton exhibited by some unusual nor-sesquiterpenes isolated from marine sources, is described. Our strategy was applied for the total synthesis of pathylactone A, which has now been prepared by an unambiguous route and found to be different from the natural product. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00058-3

文献信息

• [EN] MACROCYCLIC 1,3-BRIDGED 6-CHLORO-7-PYRAZOL-4-YL-1H-INDOLE-2-CARBOXYLATE AND 6-CHLORO-7-PYRIMIDIN-5-YL-1H-INDOLE-2-CARBOXYLATE DERIVATIVES AS MCL-1 INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS MACROCYCLIQUES DE 6-CHLORO-7-PYRAZOL-4-YL-1H-INDOLE-2-CARBOXYLATE ET 6-CHLORO-7-PYRIMIDIN-5-YL-1H-INDOLE-2-CARBOXYLATE 1,3-PONTÉS EN TANT QU'INHIBITEURS DE MCL-1 POUR LE TRAITEMENT DU CANCER
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2022171782A1

  公开（公告）日：2022-08-18

  The present invention relates to compounds of formula (I) wherein XI is as myeloid cell leukemia-1 (MCL-1) inhibitors for the treatment of cancer, such as e.g. prostate, lung, pancreatic, breast, ovarian, and cervical cancer, melanoma, B-cell chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL). An exemplary compound is e.g. compound 1

  本发明涉及式(I)的化合物，其中XI为髓系细胞白血病-1（MCL-1）抑制剂，用于治疗癌症，例如前列腺癌、肺癌、胰腺癌、乳腺癌、卵巢癌、宫颈癌、黑色素瘤、B细胞慢性淋巴细胞白血病（CLL）、急性髓系白血病（AML）和急性淋巴细胞白血病（ALL）。其中一种示例化合物为化合物1。