(2R)-2-[(3aR,6S,7R)-7-prop-2-enoxy-3a,4,6,7-tetrahydro-3H-pyrano[4,3-c][1,2]oxazol-6-yl]-2-phenylmethoxyacetaldehyde | 325797-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-[(3aR,6S,7R)-7-prop-2-enoxy-3a,4,6,7-tetrahydro-3H-pyrano[4,3-c][1,2]oxazol-6-yl]-2-phenylmethoxyacetaldehyde
• CAS: 325797-41-9
• 化学式: C₁₈H₂₁NO₅
• 分子量: 331.368
• InChiKey: UYJVRMFHXFRARF-CYGHRXIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R)-2-[(3aR,6S,7R)-7-prop-2-enoxy-3a,4,6,7-tetrahydro-3H-pyrano[4,3-c][1,2]oxazol-6-yl]-2-phenylmethoxyacetaldehyde 在 吡啶 、 sodium hypochlorite 、 盐酸羟胺 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 33.0h， 生成
  参考文献：
  名称：

  Synthesis of chiral oxepinopyran and oxepinooxepane systems from 1,2-isopropylidene furanoside ring-fused cyclic ether derivatives through 4-O-allyl nitrone and nitrile oxide cycloadditions

  摘要：

  A novel strategy was developed by which chiral oxepinopyran and oxepinooxepane derivatives were synthesised from 1,2-isopropylidene furanoside fused pyran and oxepane derivatives by the cycloaddition of 4-O-allyl nitrone or nitrile oxide species generated from the furanoside ring. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01802-5
• 作为产物：
  描述：

  (3aR,5aS,5bR,8aR,9aR)-7,7-Dimethyl-3a,4,5a,5b,8a,9a-hexahydro-3H-2,5,6,8,9-pentaoxa-1-aza-cyclopenta[b]-as-indacene 在 盐酸 、 sodium hydroxide 、 四丁基溴化铵 、 对甲苯磺酸 、 三氟乙酸 、 calcium carbonate 、 mercury dichloride 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 77.0h， 生成 (2R)-2-[(3aR,6S,7R)-7-prop-2-enoxy-3a,4,6,7-tetrahydro-3H-pyrano[4,3-c][1,2]oxazol-6-yl]-2-phenylmethoxyacetaldehyde
  参考文献：
  名称：

  Synthesis of chiral oxepinopyran and oxepinooxepane systems from 1,2-isopropylidene furanoside ring-fused cyclic ether derivatives through 4-O-allyl nitrone and nitrile oxide cycloadditions

  摘要：

  A novel strategy was developed by which chiral oxepinopyran and oxepinooxepane derivatives were synthesised from 1,2-isopropylidene furanoside fused pyran and oxepane derivatives by the cycloaddition of 4-O-allyl nitrone or nitrile oxide species generated from the furanoside ring. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01802-5

文献信息

• Synthesis of chiral oxepinopyran and oxepinooxepane systems from 1,2-isopropylidene furanoside ring-fused cyclic ether derivatives through 4-O-allyl nitrone and nitrile oxide cycloadditions
  作者：Arani Pal、Anup Bhattacharjya、Ranjan Mukhopadhyay

  DOI：10.1016/s0040-4039(00)01802-5

  日期：2000.12

  A novel strategy was developed by which chiral oxepinopyran and oxepinooxepane derivatives were synthesised from 1,2-isopropylidene furanoside fused pyran and oxepane derivatives by the cycloaddition of 4-O-allyl nitrone or nitrile oxide species generated from the furanoside ring. (C) 2000 Elsevier Science Ltd. All rights reserved.