1-(1,3-benzodioxol-5-yl)-N-methylmethanimine oxide | 1075226-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1-(1,3-benzodioxol-5-yl)-N-methylmethanimine oxide
• CAS: 1075226-91-3；63418-54-2；603125-96-8
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: QJLNAJPMGGSMKJ-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(1,3-benzodioxol-5-yl)-N-methylmethanimine oxide 、 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-D-gluco-hept-1-enitol 以 二乙二醇二甲醚 为溶剂， 反应 0.03h， 生成 (3S,5S,7R,8R,9S,10R)-3-(benzo[d][1,3]dioxol-5-yl)-8,9,10-tris(benzyloxy)-7-((benzyloxy)methyl)-2-methyl-1,6-dioxa-2-azaspiro[4.5]decane 、 (3S,5R,7R,8R,9S,10R)-3-(benzo[d][1,3]dioxol-5-yl)-8,9,10-tris(benzyloxy)-7-((benzyloxy)methyl)-2-methyl-1,6-dioxa-2-azaspiro[4.5]decane
  参考文献：
  名称：

  Stereoselective synthesis and biological activity of novel spiro-oxazinanone-C-glycosides

  摘要：

  The stereoselective synthesis of novel spiro-oxazinanone nucleosides 9 and 10 has been achieved by microwave assisted 1,3-dipolar cycloaddition of exo-glucal (1) and nitrones (2), and followed by reduction, stereospecific recyclization, and catalytic deprotection. The structures of the spironucleosides were determined according to the H-1 NMR, C-13 NMR, 2D NMR, MS, and X-ray analyses, and the biological activities of the title compounds against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and cytotoxicity were also evaluated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.002
• 作为产物：
  描述：

  LJ-2477 、 N-甲基羟胺-O-磺酸 以90%的产率得到
  参考文献：
  名称：

  ABOU-GHARBIA M.; JOULLIE M. M., SYNTHESIS, 1977, NO 5, 318-320

  摘要：

  DOI：

文献信息

• STAMM H.; STEUDLE H., TETRAHEDRON, 1979, 35, NO 5, 647-650
  作者：STAMM H.、 STEUDLE H.

  DOI：——

  日期：——
• Stereoselective synthesis and biological activity of novel spiro-oxazinanone-C-glycosides
  作者：Xiaoliu Li、Rui Wang、Yanpo Wang、Hua Chen、Zhiwei Li、Cuilan Ba、Jinchao Zhang

  DOI：10.1016/j.tet.2008.08.002

  日期：2008.10

  The stereoselective synthesis of novel spiro-oxazinanone nucleosides 9 and 10 has been achieved by microwave assisted 1,3-dipolar cycloaddition of exo-glucal (1) and nitrones (2), and followed by reduction, stereospecific recyclization, and catalytic deprotection. The structures of the spironucleosides were determined according to the H-1 NMR, C-13 NMR, 2D NMR, MS, and X-ray analyses, and the biological activities of the title compounds against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and cytotoxicity were also evaluated. (C) 2008 Elsevier Ltd. All rights reserved.
• ABOU-GHARBIA M.; JOULLIE M. M., SYNTHESIS, 1977, NO 5, 318-320
  作者：ABOU-GHARBIA M.、 JOULLIE M. M.

  DOI：——

  日期：——