ethyl 1-diethoxythiophosphinyl-1-cyclobutanecarboxylate | 145981-04-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 1-diethoxythiophosphinyl-1-cyclobutanecarboxylate
• 英文别名: Ethyl 1-diethoxyphosphinothioylcyclobutane-1-carboxylate
• CAS: 145981-04-0
• 化学式: C₁₁H₂₁O₄PS
• 分子量: 280.325
• InChiKey: KJHGYVKCQQYYLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  76.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 1-diethoxythiophosphinyl-1-cyclobutanecarboxylate 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以92%的产率得到1-diethoxythiophosphinyl-1-cyclobutanecarboxylic acid
  参考文献：
  名称：

  Synthesis of thiophosphoryl-substituted derivatives of cycloalkanecarboxylic acids

  摘要：

  The 1-thiophosphorylated esters and nitriles of cycloalkanecarboxylic acids were obtained both by the direct reaction of derivatives of thiophosphorylacetic acids with alpha,omega-dihalogenoalkanes in the K2CO3/DMSO heterophasic system, and as a result of the reaction of the corresponding oxygen compounds with the Louson reagent.

  DOI：

  10.1007/bf00869520
• 作为产物：
  描述：

  ethyl 1-diethoxyphosphinyl-1-cyclobutanecarboxylate 在 劳森试剂 作用下， 以 邻二甲苯 为溶剂， 反应 5.0h， 以80%的产率得到ethyl 1-diethoxythiophosphinyl-1-cyclobutanecarboxylate
  参考文献：
  名称：

  Synthesis of thiophosphoryl-substituted derivatives of cycloalkanecarboxylic acids

  摘要：

  The 1-thiophosphorylated esters and nitriles of cycloalkanecarboxylic acids were obtained both by the direct reaction of derivatives of thiophosphorylacetic acids with alpha,omega-dihalogenoalkanes in the K2CO3/DMSO heterophasic system, and as a result of the reaction of the corresponding oxygen compounds with the Louson reagent.

  DOI：

  10.1007/bf00869520

文献信息

• Synthesis of thiophosphoryl-substituted derivatives of cycloalkanecarboxylic acids
  作者：P. V. Kazakov、I. L. Odinets、P. V. Petrovskii、L. V. Kovalenko、T. A. Mastryukova

  DOI：10.1007/bf00869520

  日期：1992.2

  The 1-thiophosphorylated esters and nitriles of cycloalkanecarboxylic acids were obtained both by the direct reaction of derivatives of thiophosphorylacetic acids with alpha,omega-dihalogenoalkanes in the K2CO3/DMSO heterophasic system, and as a result of the reaction of the corresponding oxygen compounds with the Louson reagent.