tert-butyl 6-(3-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)-4-(benzyloxy)phenyl)hex-5-ynoate | 1266105-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 6-(3-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)-4-(benzyloxy)phenyl)hex-5-ynoate
• CAS: 1266105-12-7
• 化学式: C₂₈H₃₂O₆
• 分子量: 464.558
• InChiKey: LTVYKUHCRCQNEX-HIXSDJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  34.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 6-(3-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)-4-(benzyloxy)phenyl)hex-5-ynoate 在 10% palladium on activated carbon 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 20.0 ℃ 、405.33 kPa 条件下， 以100%的产率得到tert-butyl 6-(3-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)-4-(hydroxy)phenyl)hexanoate
  参考文献：
  名称：

  Concise and modular synthesis of regioisomeric haptens for the production of high-affinity and stereoselective antibodies to the strobilurin azoxystrobin

  摘要：

  The immune response to regioisomeric haptens of azoxystrobin with varied derivatization sites was studied. Based on the Sonogashira and Suzuki-Miyaura couplings and following a straightforward modular design, we have synthesized four haptens with the same linker anchored through C-C bonds and located at different sites of the molecule. The most stereoselective antibodies were produced from immunogens with the spacer arm at a distal position from the beta-methoxyacrylate moiety characteristic of strobilurins. Moreover, we observed that assay cross-reactivity was reliant on the functionalization site of the competitor derivative. Finally, the antibody binding site was explored using synthetic chemical analogues. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2010.11.054
• 作为产物：
  描述：

  2,4-二溴苯酚 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium phosphate 、 copper(l) iodide 、 四(三苯基膦)钯 、 正丁基锂 、 potassium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 乙醚 、 正己烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.7h， 生成 tert-butyl 6-(3-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)-4-(benzyloxy)phenyl)hex-5-ynoate
  参考文献：
  名称：

  Concise and modular synthesis of regioisomeric haptens for the production of high-affinity and stereoselective antibodies to the strobilurin azoxystrobin

  摘要：

  The immune response to regioisomeric haptens of azoxystrobin with varied derivatization sites was studied. Based on the Sonogashira and Suzuki-Miyaura couplings and following a straightforward modular design, we have synthesized four haptens with the same linker anchored through C-C bonds and located at different sites of the molecule. The most stereoselective antibodies were produced from immunogens with the spacer arm at a distal position from the beta-methoxyacrylate moiety characteristic of strobilurins. Moreover, we observed that assay cross-reactivity was reliant on the functionalization site of the competitor derivative. Finally, the antibody binding site was explored using synthetic chemical analogues. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2010.11.054