5-(3,4-dimethyl-phenoxymethyl)-oxazolidin-2-one | 102871-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(3,4-dimethyl-phenoxymethyl)-oxazolidin-2-one
• 英文别名: 5-(3,4-Xylyloxymethyl)-2-oxazolidinone；5-[(3,4-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
• CAS: 102871-73-8
• 化学式: C₁₂H₁₅NO₃
• mdl: MFCD18431461
• 分子量: 221.256
• InChiKey: JLXQUPQQJIJRCC-UHFFFAOYSA-N

物化性质

• 沸点：
  456.8±14.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(3,4-dimethyl-phenoxy)-propane-1,2-diol 、 尿素 反应 5.0h， 生成 5-(3,4-dimethyl-phenoxymethyl)-oxazolidin-2-one
  参考文献：
  名称：

  5-Aryloxymethyl-2-oxazolidinones

  摘要：

  DOI：

  10.1021/ja01490a037

文献信息

• Novel metaxalone compositions
  申请人：Pruitt D. John

  公开号：US20050063913A1

  公开（公告）日：2005-03-24

  The present invention is directed to nanoparticulate compositions comprising metaxalone. The metaxalone particles of the composition have an effective average particle size of less than about 2 microns.

  本发明涉及包含美他沙酮的纳米颗粒组合物。组合物中的美他沙酮颗粒的有效平均粒径小于约 2 微米。
• NOVEL METAXALONE COMPOSITIONS
  申请人：Elan Pharma International Limited

  公开号：EP1651189B1

  公开（公告）日：2008-12-03
• METAXALONE FORMULATIONS AND METHODS FOR THE PREPARATION THEREOF
  申请人：TEVA PHARMACEUTICAL INDUSTRIES LTD.

  公开号：EP1965795A2

  公开（公告）日：2008-09-10
• Metaxalone formulations and methods for the preparation thereof
  申请人：Azaria Abrutzky Caroline

  公开号：US20070249694A1

  公开（公告）日：2007-10-25

  The invention provides pharmaceutical metaxalone compositions having improved bioavailability, food effect, and/or relative food effect, as well as methods of making such metaxalone compositions.
• [EN] NOVEL METAXALONE COMPOSITIONS<br/>[FR] NOUVELLES COMPOSITIONS DE METAXALONE
  申请人：ELAN PHARMA INT LTD

  公开号：WO2005016310A1

  公开（公告）日：2005-02-24

  The present invention is directed to nanoparticulate compositions comprising metaxalone. The metaxalone particles of the composition have an effective average particle size of less than about 2 microns.