tert-butyl N-[2-hydroxy-1-(naphthalen-2-yl)ethyl]carbamate | 896132-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-butyl N-[2-hydroxy-1-(naphthalen-2-yl)ethyl]carbamate
• 英文别名: tert-butyl N-(2-hydroxy-1-naphthalen-2-ylethyl)carbamate
• CAS: 896132-17-5
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: FMVNDTVKQQHSNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-hydroxy-1-(naphthalen-2-yl)ethyl]carbamate 在 sodium t-butanolate 作用下， 以 四氢呋喃 为溶剂， 以76%的产率得到4-(naphthalen-2-yl)oxazolidin-2-one
  参考文献：
  名称：

  Kinetic Resolution of 2-Oxazolidinones via Catalytic, Enantioselective N-Acylation

  摘要：

  Kinetic resolution of racemic 2-oxazolidinones via catalytic, enantioselective N-acylation has been achieved for the first time and with outstanding selectivities.

  DOI：

  10.1021/ja061560m
• 作为产物：
  描述：

  2-amino-2-(naphthalen-2-yl)acetonitrile 在 盐酸 、 sodium tetrahydroborate 、 氯化亚砜 、 三乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 生成 tert-butyl N-[2-hydroxy-1-(naphthalen-2-yl)ethyl]carbamate
  参考文献：
  名称：

  Kinetic Resolution of 2-Oxazolidinones via Catalytic, Enantioselective N-Acylation

  摘要：

  Kinetic resolution of racemic 2-oxazolidinones via catalytic, enantioselective N-acylation has been achieved for the first time and with outstanding selectivities.

  DOI：

  10.1021/ja061560m

文献信息

• Arylcyclopropylcarboxylic amides as potassium channel openers
  申请人：——

  公开号：US20040110754A1

  公开（公告）日：2004-06-10

  The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I 1 wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said arylcyclopropylcarboxylic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.

  本发明提供了具有一般式I1的新型芳基环丙基羧酰胺和相关衍生物，其中R、R1、R2、R3、R4、R5、R6和R7如规范中所定义，或其无毒的药学上可接受的盐、溶剂或水合物，这些化合物是KCNQ钾通道的开启剂或激活剂。本发明还提供了包括上述芳基环丙基羧酰胺的药物组合物，以及治疗对KCNQ钾通道开启活性敏感的疾病的方法，如偏头痛或偏头痛发作、双相障碍、癫痫、急性和慢性疼痛以及焦虑症。
• 1-aryl-2-hydroxyethyl amides as potassium channel openers
  申请人：——

  公开号：US20040122007A1

  公开（公告）日：2004-06-24

  The present invention provides novel aryl hydroxyethyl amides and related derivatives having the general Formula I 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and A are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said aryl hydroxyethyl amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.

  本发明提供了新型芳基羟乙基酰胺和相关衍生物，其具有一般式I1，其中R1、R2、R3、R4、R5、R6、R7和A如规范中所定义，或其无毒药物可接受的盐、溶剂或水合物，可作为KCNQ钾通道的开放剂或激活剂。本发明还提供了包括上述芳基羟乙基酰胺的药物组合物，以及治疗对KCNQ钾通道开放活性敏感的疾病的方法，例如偏头痛或偏头痛发作、双相障碍、癫痫、急性和慢性疼痛以及焦虑症。
• Perhydrothiazepine derivatives, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0161801A2

  公开（公告）日：1985-11-21

  Compounds of formula (I): (wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl, cycloalkyl, aralkyl, aryl, heterocyclic or heterocyclic-alkyl group or any adjacent pair thereof form a cyclic structure, at least one not being hydrogen; A represents a bond, or a methylene, ethylene, oxymethyl or thiomethyl group; B represents an alkylene, alkylidene, cycloalkylene or cycloalkylidene group; and n is 0, 1 or 2) and salts and esters thereof are hypotensive agents.

  式（I）化合物（其中：R1 代表任选取代的烷基、环烷基、芳基、部分氢化的芳基或杂环基团；R2、R3、R4 和 R5 代表氢或任选取代的烷基、环烷基、芳基、芳基、杂环基或杂环-烷基基团或其任何相邻对形成的环状结构，其中至少有一个不是氢；A 代表键，或亚甲基、亚乙基、氧甲基或硫甲基基团；B 代表亚烷基、亚烷基、环烷基或亚环烷基基团；n 为 0、1 或 2）及其盐和酯类是降血压剂。
• US7045551B2
  申请人：——

  公开号：US7045551B2

  公开（公告）日：2006-05-16
• US7144881B2
  申请人：——

  公开号：US7144881B2

  公开（公告）日：2006-12-05