四(羟基甲基)鏻氢氧化物 | 512-82-3

• 分子结构分类: 有机化合物 - 有机磷化合物 - 四烷基鏻化合物
• 中文名称: 四(羟基甲基)鏻氢氧化物
• 英文名称: tetrakis(hydroxymethyl)phosphonium hydroxide
• 英文别名: tetrakis-hydroxymethyl-phosphonium; hydroxide；tetrakis-(hydroxymethyl)-phosphonium hydroxide；tetrakis(hydroxymethyl)-phosphonium hydroxide；Tetrakis-(hydroxymethyl)-phosphoniumhydroxid；Tetrakis-hydroxymethyl-phosphonium-hydroxid；Phosphonium, tetrakis(hydroxymethyl)-, hydroxide；tetrakis(hydroxymethyl)phosphanium;hydroxide
• CAS: 512-82-3
• 化学式: C₄H₁₂O₄P*HO
• 分子量: 172.118
• InChiKey: IOIHFHNPXJFODN-UHFFFAOYSA-M

物化性质

• 溶解度：
  Soluble in water.

计算性质

• 辛醇/水分配系数(LogP)：
  -1.37
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.9
• 氢给体数：
  5
• 氢受体数：
  5

ADMET

毒理性

• 毒性总结

氯化四(羟甲基)磷onium (THPC) 和硫酸四(羟甲基)磷onium (THPS) 的急性口服毒性为中等；皮肤毒性较低。在短期（长达28天）的大鼠和小鼠研究中，THPC和THPS的主要毒性效应是体重下降。... 在较长期的研究中（13周），主要毒性靶器官是肝脏。... 对THPC进行的致癌性生物检测也显示出对肝脏的影响... THPS在单次给药于兔子上时并未引起皮肤刺激。然而，大鼠的重复皮肤暴露导致了严重的皮肤反应。THPC具有腐蚀性。THPS在兔子上被识别为严重的眼刺激物。THPS和THPC-脲能引起豚鼠的皮肤致敏... THPS和THPC-脲在口服给药的实验动物中并未引起发育毒性。没有确凿的证据表明用THP盐处理的织物具有致突变性。现有信息表明，对人类没有基因毒性危害。在为期两年的生物检测中，THPC和THPS在大鼠和小鼠中并未表现出致癌性。皮肤研究表明，THP盐是皮肤癌症的促进剂，但不是启动剂。THPS和THPO（三羟甲基磷ine氧化物）在体外并未抑制乙酰胆碱酯酶活性，这表明对人类没有神经毒性危害。THPC-脲处理的织物并未在人类中引起皮肤刺激。... 目前没有关于人类或环境中生物的暴露信息。因此，无法进行定量风险评估。

The acute oral toxicity of /tetrakis(hydroxymethyl)phosphonium chloride (THPC) and tetrakis(hydroxymethyl)phosphonium sulfate (THPS)/ is moderate; dermal toxicity is low. In short term (up to 28 days) studies in rats and mice, the main toxic effect for both THPC and THPS is decreased body weight. ... In longer term studies, (13 weeks), the main target organ for toxicity is the liver. ... Carcinogenicity bioassays on THPC also showed effects on the liver ... THPS did not cause skin irritation when administered as a single dose to rabbits. However, repeated dermal exposure of rats resulted in severe skin reaction. THPC was corrosive. THPS was identified as severe eye irritant in rabbits. THPS and THPC-urea cause skin sensitization guinea pigs ... THPS and THPC-urea did not cause developmental toxicity in orally dosed experimental animals. There is no convincing evidence to suggest that fabrics treated with THP salts are mutagenic. Available information indicates that there is no genotoxic hazard to humans. THPC and THPS were not carcinogenic in rats and mice in 2-year bioasssays. Dermal studies have shown that THP salts are promoters of skin cancer but not initiators. THPS and THPO /trihydroxylmethylphosphine oxide/ did not inhibit acetylcholinesterase activity in vitro, suggesting a lack of neurotoxic hazard for humans. THPC-urea treated fabrics did not cause skin irritation in humans. ... No exposure information is available for either humans or organisms in the environment. Therefore, no quantitative risk assessment could be made.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，并在需要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……监测休克，并在必要时进行治疗……预计癫痫发作，并在必要时进行治疗……对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……在去污后，用干燥的无菌敷料覆盖皮肤烧伤……/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。开始静脉输液，使用D5W（5%葡萄糖溶液）/SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎输液。注意液体过载的迹象。使用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/毒药A和B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

阻燃剂的有毒性，包括三(2,3-二溴丙基)磷酸盐、PyrovateX CP和四羟甲基磷酸氢(THPOH)，在一项为期30天的实验中用金鱼进行了研究。在1 ppm的浓度下，THPOH的毒性大于PyrovateX CP但小于三(2,3-二溴丙基)磷酸盐。所有暴露在三(2,3-二溴丙基)磷酸盐中的鱼在5天内全部死亡。

THE TOXICITY OF THE FLAME RETARDANTS, TRIS(2,3-DIBROMOPROPYL)PHOSPHATE, PYROVATEX CP, & TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM HYDROXIDE (THPOH), WERE STUDIED IN A 30-DAY EXPERIMENT WITH GOLDFISH. AT A CONCN OF 1 PPM, THPOH WAS MORE TOXIC THAN PYROVATEX CP BUT LESS TOXIC THAN TRIS(2,3-DIBROMOPROPYL)PHOSPHATE. ALL FISH EXPOSED TO TRIS(2,3-DIBROMOPROPYL)PHOSPHATE WERE DEAD WITHIN 5 DAYS.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  四(羟基甲基)鏻氢氧化物 在 五氯化磷 作用下， 以 四氯化碳 为溶剂， 生成 tetrakis(chloromethyl)phosphonium chloride
  参考文献：
  名称：

  Raver,Kh.R. et al., Journal of general chemistry of the USSR, 1962, vol. 32, # 2, p. 578 - 580

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 在 水 、 phosphan 作用下， 生成 四(羟基甲基)鏻氢氧化物
  参考文献：
  名称：

  Raver,Kh.R. et al., Journal of general chemistry of the USSR, 1962, vol. 32, # 2, p. 578 - 580

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-叠氮丙二酸二甲酯 、 2-苯基-1-丙烯 在 四(羟基甲基)鏻氢氧化物 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 12.0h， 以41%的产率得到dimethyl 2-methyl-2-phenylcyclopropane-1,1-dicarboxylate
  参考文献：
  名称：

  路易斯酸介导的 (3 + 2) 供体-受体环丙烷与杂草烯的环加成反应

  摘要：

  异氰酸酯、异硫氰酸酯和碳二亚胺是与供体-受体环丙烷进行 (3 + 2) 环加成反应的有效底物，用于合成五元杂环。这些反应表现出广泛的底物范围、高产率和明确的化学选择性。本文讨论的是路易斯酸选择对立体化学结果和反应机理的影响。

  DOI：

  10.1021/ol302494n

文献信息

• Raver,Kh.R. et al., Journal of general chemistry of the USSR, 1962, vol. 32, # 2, p. 578 - 580
  作者：Raver,Kh.R. et al.

  DOI：——

  日期：——