2-苯胺基-5-噻唑啉酮 | 55620-29-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-苯胺基-5-噻唑啉酮
• 英文名称: 2-phenylaminothiazolidin-4-one
• 英文别名: 2-anilino-4H-1,3-thiazol-5-one
• CAS: 55620-29-6
• 化学式: C₉H₈N₂OS
• 分子量: 192.241
• InChiKey: HRTNVZOWEFVIGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  321.0±25.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苯胺基-5-噻唑啉酮 在 三氯氧磷 作用下， 反应 6.0h， 生成 5-hydroxy-2-phenylaminothiazolo<4.5-d>pyrimidine
  参考文献：
  名称：

  Pawar, R. A.; Rajput, A. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 866 - 867

  摘要：

  DOI：

文献信息

• An Efficient Approach for the Synthesis and Antitumor Evaluation of Novel Azo‐ and Anil‐Linked with 3‐Aminopyrazolo[3,4‐b]pyridine
  作者：Ghada G. El‐Bana、Wafaa S. Hamama、Hanafi H. Zoorob、Mona E. Ibrahim

  DOI：10.1002/cbdv.202300156

  日期：2023.6

  corresponding aldimine 14, 15, 16. Compound 15 was cyclized via refluxing in DMF for 6 h to afford 18, while the transformation of compound 16 with an alkyl halide afforded 19a, b. The synthesized compounds, explicated by spectral data and elemental analysis, were examined for their antitumor activities. The in vitro cytotoxic activity of new pyrazolo[3,4-b]pyridines against the A2780CP, MCF-7, and HepG-2

  在该项目中，通过杂环胺1 的重氮盐2与活性亚甲基、烯胺和脒部分（如3、5、7、和9在0-5℃下在吡啶中反应，分别得到肼基亚肼基衍生物4、二氮烯基杂环衍生物6、8和10。此外，氨基吡唑并[3,4-b]吡啶1与不同的芳基或杂芳基醛在 EtOH/AcOH 中缩合，得到相应的醛亚胺14，15、16。_ _ 化合物15通过在DMF中回流6小时环化得到18 ，而化合物16用烷基卤化物转化得到19a、  b。通过光谱数据和元素分析解释合成的化合物，并检查其抗肿瘤活性。使用参考阿霉素评估新型吡唑并[3,4-b]吡啶对A2780CP、MCF-7和HepG-2细胞系的体外细胞毒活性。化合物15和19a对 A2780CP 细胞系表现出高反应性，IC 50值分别为 35 和 17.9 μM。此外，化合物28对 A2780CP 和 MCF-7 细胞系具有潜在的细胞毒性，IC 50值分别为 14.5 和 27.8 μM。
• Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and DNA and transformed cell intermediates therefor
  申请人：GENENTECH, INC.

  公开号：EP0093619A1

  公开（公告）日：1983-11-09

  Human tissue plasminogen activator (t-PA) is produced In useful quantities using recombinant techniques. This invention thus enables production of t-PA free of contaminants associated with it in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.

  人组织纤溶酶原激活剂（t-PA）是利用重组技术生产出来的。因此，本发明能够生产出在原生细胞环境中没有污染物的 t-PA。本发明还公开了用于生产的方法、表达载体和各种宿主细胞。
• Process for producing heterologous protein in yeast, expression vehicle therefor, and yeast transformed therewith
  申请人：GENENTECH, INC.

  公开号：EP0127304A1

  公开（公告）日：1984-12-05

  The secretion from yeast of heterologous protein via a preprotein in which the heterologous protein is fused to the signal peptide of a yeast protein. The preprotein is processed by the cells to produce and secrete mature heterologous protein.

  通过预蛋白从酵母中分泌异源蛋白，其中异源蛋白与酵母蛋白的信号肽融合。预蛋白经细胞处理后产生并分泌成熟的异源蛋白。
• A method for detecting amino acid derivatives
  申请人：SEIKO INSTRUMENTS INC.

  公开号：EP0353361A1

  公开（公告）日：1990-02-07

  A method for detecting an amino acid derivative comprises the steps of: reacting a 2-anilino-5-­thiazolinone derivative of the general formula (a) below with an amino compound of fluorescein or an amino compound of rhodamine derivatives of the general formula (b) below to form a phenylthiocarbamyl amino acid derivative of the general formula (c) below; and detecting said phenylthio-carbamyl amino acid derivative wherein X is a fluorescein or a rhodamine derivative and R1 is an amino acid side chain.

  一种检测氨基酸衍生物的方法，包括以下步骤： 将以下通式(a)的 2-苯胺基-5-噻唑啉酮衍生物与以下通式(b)的荧光素的氨基化合物或罗丹明衍生物的氨基化合物反应，形成以下通式(c)的苯硫基氨基甲酸酯衍生物；检测所述苯硫基氨基甲酸酯衍生物。 其中 X 为荧光素或罗丹明衍生物，R1 为氨基酸侧链。
• Novel metal complex and method for determining amino acid sequence of protein using the same
  申请人：——

  公开号：US20040029181A1

  公开（公告）日：2004-02-12

  The present invention provides a novel metal complex useful for a reagent for determining the amino acid sequence of protein or peptide, and a method of using it for determining the amino acid sequence of protein or peptide. The metal complex which has a functional group capable of forming a covalent bond with the amino group of the N-terminal amino acid residue of protein or peptide or with the carboxyl group of the C-terminal amino acid residue of protein or peptide. In general, the functional group is in the ligand of the complex. The metal complex is reacted with a protein or peptide (A) of which the amino acid sequence is to be determined, to thereby obtain a metal complex derivative (B) where the covalent bond of the functional group of the metal complex with the amino group of the N-terminal amino acid residue of the protein or peptide (A) or with the carboxyl group of the C-terminal amino acid residue of protein or peptide is formed, and the derivative (B) is analyzed through mass spectrometry to determine the amino acid sequence of the protein or peptide (A).

  本发明提供了一种可用于测定蛋白质或肽的氨基酸序列的试剂的新型金属络合物，以及使用它测定蛋白质或肽的氨基酸序列的方法。该金属复合物具有能与蛋白质或肽的 N 端氨基酸残基的氨基或 C 端氨基酸残基的羧基形成共价键的官能团。一般来说，官能团位于络合物的配体中。金属络合物与氨基酸序列有待确定的蛋白质或肽 (A) 反应，从而得到金属络合物衍生物 (B)，其中金属络合物的官能团与蛋白质或肽 (A) N 端氨基酸残基的氨基或与蛋白质或肽 C 端氨基酸残基的羧基形成共价键、并通过质谱分析衍生物 (B)，以确定蛋白质或肽 (A) 的氨基酸序列。