N,N-Bis(3-acetamidopropyl)-acetamid | 62371-84-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-Bis(3-acetamidopropyl)-acetamid
• 英文别名: N-[3-[3-acetamidopropyl(acetyl)amino]propyl]acetamide
• CAS: 62371-84-0
• 化学式: C₁₂H₂₃N₃O₃
• 分子量: 257.333
• InChiKey: QBJLCDARCWAQPH-UHFFFAOYSA-N

物化性质

• 沸点：
  559.2±35.0 °C(Predicted)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-Bis-(3-acetamidopropyl)-p-toluolsulfonamid 、 sodium acetate 生成 N,N-Bis(3-acetamidopropyl)-acetamid
  参考文献：
  名称：

  异构体和同源亚精胺和亚精胺衍生物的合成及其质谱鉴定（作者译）。

  摘要：

  Synthesis of isomeric and homologous spermidine and spermine derivatives and their identification by mass spectrometry.The structure of homologous and isomeric spermidines and spermines follows from mass‐spectroscopical analysis of their peracetyl (see text, footnote 3) (Table 1) or tosyl‐acetyl (Table 2) derivatives. In the case of the peracetyl compounds, triads of peaks are recorded which, according to the number of methylene groups between the nitrogen atoms, show mass numbers characteristic for each of the substances (Scheme 1, ions b, d, e and c).On the basis of cyclic ions of type f (Scheme 2), occurring in the mass spectra of N‐acetyl derivatives, tosylated on a secondary amino nitrogen atom, deductions can be drawn as to the number of methylene groups between neighbouring tosylated and acetylated nitrogen atoms in these compounds.

  DOI：

  10.1002/hlca.19770600114

文献信息

• Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
  申请人：Nielson Loretta

  公开号：US20070014768A1

  公开（公告）日：2007-01-18

  In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor suppressor nucleic acid and also contacting said cell with at least one adjunctive anti-cancer agent. The invention also provides for a pharmacological composition comprising a tumor suppressor protein or a tumor suppressor nucleic acid and at least one adjunctive anti-cancer agent, and a kit for the treatment of mammalian cancer or hyperproliferative cells.
• COMBINED TUMOR SUPPRESSOR GENE THERAPY AND CHEMOTHERAPY IN THE TREATMENT OF NEOPLASMS
  申请人：Nielsen Loretta

  公开号：US20070122379A1

  公开（公告）日：2007-05-31

  In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor suppressor nucleic acid and also contacting said cell with at least one adjunctive anti-cancer agent. The invention also provides for a pharmacological composition comprising a tumor suppressor protein or a tumor suppressor nucleic acid and at least one adjunctive anti-cancer agent, and a kit for the treatment of mammalian cancer or hyperproliferative cells.
• METHODS OF COMPOSITIONS FOR THE TREATMENT OF OCULAR DISEASES
  申请人：DEMERS G. William

  公开号：US20090148508A1

  公开（公告）日：2009-06-11

  Methods and compositions for the treatment of ocular disease with a cyclin dependent kinase inhibitor are provided.
• COMPOSITIONS AND METHODS FOR THERAPEUTIC USE
  申请人：Engler Heidrun

  公开号：US20100028431A1

  公开（公告）日：2010-02-04

  A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X 1 is a cholic acid group or deoxycholic acid group; and X 2 and X 3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X 2 and X 3 is a saccharide group.
• 5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL
  申请人：BASF SE

  公开号：US20160362535A1

  公开（公告）日：2016-12-15

  A composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation; and b) a compound of formula I (Formula I) (I) where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are independently from each other H, C 1 -C 8 -alkyl, C 4 -C 8 -cycloalkyl, phenyl, C 1 -C 4 -alkoxy or halogen; n is 1, 2, 3, or 4; and when n is 1 A is —C(=0)-OR′ 1 , —C(=0)-N(R ′2 )(R′ 3 ), —CN, phenyl, which is unsubstituted or substituted by one or more C 1 -C 8 -alkyl, C 4 -C 8 -alkoxy, C 5 -C 7 -cycloalkyl or halogen, —H or —S0 2 -phenyl; when n is 2 A is —C(=0)-0-Z 1 —O—C(=0)-, —C(=0)-N(R″ 1 )—Z 2 —N(R″ 2 )—C(=0)- or piperazine-N,N′-biscarbonyl.