Mono-methyl 2-methylmuconate | 108245-53-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Mono-methyl 2-methylmuconate
• 英文别名: (2E,4E)-6-methoxy-5-methyl-6-oxohexa-2,4-dienoic acid
• CAS: 108245-53-0
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: QLLXAUQRZSMUJB-GGWOSOGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl (2E,4E)-2-methyl-6-oxohexa-2,4-dienoate 在 air 作用下， 反应 2160.0h， 生成 Mono-methyl 2-methylmuconate
  参考文献：
  名称：

  Synthesis of (±)-(E,E)-2,7-Dimethylocta-2,4-dienedioic Acid

  摘要：

  （+/--(2E,4E)-2,7-二甲基辛-2,4-二烯-1,8-二羧酸（1）通过以下方法高效合成：首先采用铑-卡宾诱导的糠环打开反应，随后依次进行非常规的NaBH4/CeCl3·7H2O还原、Wittig-Horner烯化反应以及二酯水解。

  DOI：

  10.1002/(sici)1522-2675(19990407)82:4<511::aid-hlca511>3.0.co;2-d

文献信息

• FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
  申请人：Chiu Daniel T.

  公开号：US20120282632A1

  公开（公告）日：2012-11-08

  The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

  本发明提供了功能化的色团聚合物点，包括疏水性核心和亲水性帽子，以及其生物共轭物。同时提供了改进的制备功能化色团聚合物点的方法。还揭示了用于体内成像和分子标记的方法。
• Biotracer and its use in an immunoassay
  申请人：King Saud University

  公开号：EP2653867A1

  公开（公告）日：2013-10-23

  The present invention relates to a biotracer comprising polymeric micelles and its use in an immunoassay.

  本发明涉及一种由聚合物胶束组成的生物示踪剂及其在免疫测定中的应用。
• CHROMOPHORIC POLYMER DOTS
  申请人：University of Washington through its Center for Commercialization

  公开号：EP3434642A1

  公开（公告）日：2019-01-30

  The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

  除其他方面外，本发明还提供了稳定的发色性纳米粒子。在某些实施例中，本发明提供的色素纳米粒子被合理地用预定数量的官能团官能化。在某些实施例中，本文提供的稳定的色素纳米粒子用低密度的官能团修饰。在另一些实施例中，本文提供的发色纳米粒子与一种或多种分子共轭。本文还提供了制作合理官能化的色素纳米粒子的方法。
• FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
  申请人：University Of Washington Center For Commercialization

  公开号：EP3483610A1

  公开（公告）日：2019-05-15

  The present invention provides, among other aspects, functionalized chromophoric polymer dots, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

  除其他方面外，本发明还提供了功能化发色性聚合物点及其生物共轭物。本发明还提供了制备功能化发色性聚合物点的改进方法。本发明还公开了体内成像和分子标记的方法。
• ENCODED CHROMOPHORIC POLYMER PARTICLES
  申请人：University of Washington through its Center for Commercialization

  公开号：EP3521399A1

  公开（公告）日：2019-08-07

  The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

  本公开提供了可对分析物进行光学和/或生物分子编码的编码发色性聚合物颗粒。本公开还提供了包含多个编码发色性聚合物颗粒的悬浮液。本公开还提供了使用编码发色性聚合物颗粒的方法以及使用编码发色性聚合物颗粒进行多重分析的系统。