4-methoxy-3-methyl-benzaldehyde seqtrans-oxime | 90609-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxy-3-methyl-benzaldehyde seqtrans-oxime
• 英文别名: 4-methoxy-3-methyl-benzaldehyde-oxime；4-Methoxy-3-methyl-benzaldehyd-seqtrans-oxim；α-4-Methoxy-3-methyl-benzaldehyd-oxim；4-Methoxy-3-methyl-benzaldehyd-oxim；4-methoxy-3-methylbenzaldehydeoxime；(NE)-N-[(4-methoxy-3-methylphenyl)methylidene]hydroxylamine
• CAS: 90609-89-5
• 化学式: C₉H₁₁NO₂
• 分子量: 165.192
• InChiKey: JWTUAQXEPMZDBZ-UXBLZVDNSA-N

物化性质

• 熔点：
  121 °C
• 沸点：
  267.0±33.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxy-3-methyl-benzaldehyde seqtrans-oxime 生成 4-甲氧基-3-甲基苯甲腈
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-3-甲基苯甲醛 生成 4-methoxy-3-methyl-benzaldehyde seqtrans-oxime
  参考文献：
  名称：

  Bogert; Hamann, American perfumer, 1930, vol. 25, p. 75

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED PYRAZOLES AS PPAR AGONISTS<br/>[FR] PYRAZOLES SUBSTITUES UTILISES EN TANT QU'AGONISTES DE PPAR
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005049578A1

  公开（公告）日：2005-06-02

  A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof (I) wherein: p is O or 1; q is O or 1; R1 and R2 are independently H or C1-3 alkyl; R3 and R4 are independently H, C1-6 alkyl, -OC1-6 alkyl, halogen, OH, C2-6 alkenyl or CF3; R5 is H, C1-6 alkyl (optionally substituted by one or more halogens, -COphenyl, OC1-6 alkyl, phenyl morpholino or C2-6 alkenyl. R6 is C1-6 alkyl, halogen, -OCH2 phenyl, phenyl (optionally substituted by C1-3 alkiyl), morpholino, pyrrolidino, piperidino, thiophenyl, furanyl pyridinyl or -OC2-6 alkenyl. These compounds activate the alpha and gamma subtypes fo the hppar receptor and are useful e.g. in the treatment of diabetes, dyslipidemia or syndrome X.

  式（I）的化合物及其药学上可接受的盐、溶剂化合物和可水解酯（I）其中：p为O或1；q为O或1；R1和R2独立地为H或C1-3烷基；R3和R4独立地为H、C1-6烷基、-OC1-6烷基、卤素、OH、C2-6烯基或CF3；R5为H、C1-6烷基（可选地被一个或多个卤素、-CO苯基、OC1-6烷基、苯基吗啡啉或C2-6烯基取代）。R6为C1-6烷基、卤素、-OCH2苯基、苯基（可选地被C1-3烷基取代）、吗啡啉、吡咯啉、哌啶、噻吩基、呋喃基吡啶基或-OC2-6烯基。这些化合物激活hppar受体的α和γ亚型，在糖尿病、血脂异常或X综合征的治疗中很有用。
• Amide compound and method of controlling plant disease with the same
  申请人：Sakaguchi Hiroshi

  公开号：US20060122065A1

  公开（公告）日：2006-06-08

  A amid compound of the formula (1): wherein, in the formula, R 51 represents a halogen atom, a C1-C6 alkyl group and the like; R 52 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and the like; R 53 represents a halogen atom and the like; R 56 represents a halogen atom and the like; R 57 represents a hydrogen atom and the like; R 58 and R 59 independently represent a hydrogen atom, a C1-C3 alkyl group and the like; R 60 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group, or a C3-C6 alkynyl group; R 61 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group or a C3-C6 alkynyl group or a C2-C4 cyanoalkyl group; R 62 , R 63 and R 64 represent a hydrogen atom, a halogen atom and the like; X represents a oxygen atom or a sulfur atom; has an excellent activity against plant diseases.

  一种化合物的公式（1）：其中，在公式中，R51代表卤素原子，C1-C6烷基等；R52代表氢原子，卤素原子，C1-C6烷基等；R53代表卤素原子等；R56代表卤素原子等；R57代表氢原子等；R58和R59分别独立地代表氢原子，C1-C3烷基等；R60代表C1-C4烷基，C1-C4卤代烷基，C3-C4烯基或C3-C6炔基；R61代表C1-C4烷基，C1-C4卤代烷基，C3-C4烯基或C3-C6炔基或C2-C4氰基烷基；R62，R63和R64代表氢原子，卤素原子等；X代表氧原子或硫原子；具有出色的植物病害活性。
• Substituted Pyrazoles As Ppar Agonists
  申请人：Faucher Eric Nicolas

  公开号：US20080021030A1

  公开（公告）日：2008-01-24

  A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein: p is 0 or 1; q is 0 or 1; R 1 and R 2 are independently H or C 1-3 alkyl; R 3 and R 4 are independently H, C 1-6 alkyl, —OC 1-6 alkyl, halogen, OH, C 2-6 alkenyl or CF 3 ; R 5 is H, or C 1-6 alkyl, wherein said C 1-6 alkyl is optionally substituted by one or more halogens, —COphenyl, —OC 1-6 alkyl, phenyl, morpholino, or C 2-6 alkenyl; R 6 is C 1-6 alkyl, halogen, —OCH 2 phenyl, morpholino, pyrrolidino, piperidino, thiophenyl, furanyl, pyridinyl, —OC 2-6 alkenyl, or phenyl, wherein said phenyl is optionally substituted by C 1-3 alkyl.

  化合物的分子式为（I），其药学上可接受的盐、溶剂化物和可水解酯类，其中：p为0或1；q为0或1；R1和R2独立地为H或C1-3烷基；R3和R4独立地为H、C1-6烷基、—OC1-6烷基、卤素、OH、C2-6烯基或CF3；R5为H或C1-6烷基，其中所述的C1-6烷基可以选用一个或多个卤素、—CO苯基、—OC1-6烷基、苯基、吗啉基或C2-6烯基进行取代；R6为C1-6烷基、卤素、—OCH2苯基、吗啉基、吡咯烷基、哌啶基、噻吩基、呋喃基、吡啶基、—OC2-6烯基或苯基，其中所述的苯基可以选用C1-3烷基进行取代。
• AMIDE COMPOUND AND METHOD OF CONTROLLING PLANT DISEASE WITH THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1577290A1

  公开（公告）日：2005-09-21

  A amid compound of the formula (1): wherein, in the formula, R51 represents a halogen atom, a C1-C6 alkyl group and the like; R52 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and the like; R53 represents a halogen atom and the like; R56 represents a halogen atom and the like; R57 represents a hydrogen atom and the like; R58 and R59 independently represent a hydrogen atom, a C1-C3 alkyl group and the like; R60 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group, or a C3-C6 alkynyl group; R61 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group or a C3-C6 alkynyl group or a C2-C4 cyanoalkyl group; R62, R63 and R64 represent a hydrogen atom, a halogen atom and the like; X represents a oxygen atom or a sulfur atom; has an excellent activity against plant diseases.

  一种式（1）的酰胺化合物： 式中 R51 代表卤素原子、C1-C6 烷基等； R52 代表氢原子、卤素原子、C1-C6 烷基等； R53 代表卤素原子等； R56 代表卤原子等； R57 代表氢原子等； R58 和 R59 独立地代表氢原子、C1-C3 烷基等； R60 代表 C1-C4 烷基、C1-C4 卤代烷基、C3-C4 烯基或 C3-C6 烷炔基；R61代表 C1-C4 烷基、C1-C4 卤代烷基、C3-C4 烯基或 C3-C6 炔基或 C2-C4 氰烷基；R62、R63 和 R64 代表氢原子、卤素原子等；X 代表氧原子或硫原子； 对植物病害具有极佳的活性。
• Spirocyclic inhibitors of serine proteases for the treatment of hcv infections
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP2631238A1

  公开（公告）日：2013-08-28

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.

  本发明涉及式（I）化合物或其药学上可接受的盐。这些化合物可抑制丝氨酸蛋白酶，特别是丙型肝炎病毒 NS3-NS4A 蛋白酶。