N-(2-nitrobenzyl)hydroxylamine | 37558-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-nitrobenzyl)hydroxylamine
• 英文别名: N-[(2-nitrophenyl)methyl]hydroxylamine
• CAS: 37558-77-3
• 化学式: C₇H₈N₂O₃
• 分子量: 168.152
• InChiKey: OTPVMQSPENXDJL-UHFFFAOYSA-N

物化性质

• 沸点：
  342.5±44.0 °C(Predicted)
• 密度：
  1.357±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-nitrobenzyl)hydroxylamine 、 异氰酸苯酯 在 苯 作用下， 生成 N-hydroxy-N-(2-nitro-benzyl)-N'-phenyl-urea
  参考文献：
  名称：

  Kjellin; Kuylenstjerna, Chemische Berichte, 1897, vol. 30, p. 517

  摘要：

  DOI：
• 作为产物：
  描述：

  2-硝基苯甲醛肟 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 N-(2-nitrobenzyl)hydroxylamine
  参考文献：
  名称：

  N-(1-Cyanocyclohexyl)-C-phenylnitrones and Glyoxaldinitrones

  摘要：

  Six N-(1-cyanocyclohexyl)-C-phenylnitrones 4a-f (4b-f for the first time) and 22 glyoxaldinitrones 7a-v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombotic activities. Maximum inhibition of thrombus formation in arterioles (21%) was observed in N,N'-bis-2-phenylethylglyoxaldinitrone (7o) and N,N'-bis-4-nitrobenzylglyoxaldinitrone (7u). The compounds form only small amounts of nitric oxide in vitro by the addition of a Fe3+-porphyrine complex and an oxygen donor.

  DOI：

  10.1002/(sici)1521-4184(20005)333:5<130::aid-ardp130>3.0.co;2-d

文献信息

• Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow
  作者：Clément Audubert、Alexanne Bouchard、Gary Mathieu、Hélène Lebel

  DOI：10.1021/acs.joc.8b02387

  日期：2018.11.16

  bromides and chlorides with aqueous ammonia and hydroxylamine was achieved in continuous flow to produce primary ammonium salts and hydroxylamines in high yields. An in-line workup was designed to isolate the corresponding primary amine, which was also telescoped in further reactions, such as acylation and Paal–Knorr pyrrole synthesis. Monosubstituted epoxides are also compatible with the reaction conditions

  连续流动实现烷基溴和氯化物与氨水和羟胺的化学选择性胺化，以高收率生产伯铵盐和羟胺。设计了在线后处理以分离相应的伯胺，该伯胺也可通过进一步反应进行缩合，例如酰化和Paal-Knorr吡咯合成。单取代的环氧化物也与反应条件相容。
• Synthesis of Phosphinic Amides from Chlorophosphines and Hydroxyl Amines via P(III) to P(V) Rearrangement
  作者：Fang Cheng、Dongqiu Li、Jing Li、Yuhai Tang、Yong Wu、Silong Xu

  DOI：10.1021/acs.orglett.3c00229

  日期：——

  we devised a phosphorus-containing species as a radical precursor, but without the generation of phosphorus waste. Accordingly, a catalyst-free synthesis of phosphinic amides from hydroxyl amines and chlorophosphines via P(III) to P(V) rearrangement is described. Mechanistically, it may involve the initial formation of a R2N–O–PR2 species that undergoes homolysis of N–O bonds and subsequent radical

  膦酰基是产生新自由基的重要介质，但通常会产生化学计量的氧化膦/硫化物废物。在此，我们设计了一种含磷物质作为自由基前体，但不会产生磷废物。因此，描述了通过 P(III) 到 P(V) 重排从羟基胺和氯膦无催化剂合成次膦酰胺。从机理上讲，它可能涉及 R 2 N–O–PR 2物种的初始形成，该物种经历 N–O 键的均裂和随后的自由基重组。
• Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
  申请人：Henriksen Bang Dennis

  公开号：US20050282749A1

  公开（公告）日：2005-12-22

  The present invention relates to methods for prevention and treatment of bone-related disorders and calcium homeostasis related syndromes using a GLP-2 molecule or GLP-2 activator either alone or in combination with another therapeutic. The present invention also encompasses methods of diagnosing or monitoring the progression of a disorder. The invention also encompasses methods of monitoring the effectiveness of treatment of the invention.

  本发明涉及使用 GLP-2 分子或 GLP-2 激活剂单独或与另一种疗法联合预防和治疗骨相关疾病和钙平衡相关综合征的方法。本发明还包括诊断或监测疾病进展的方法。本发明还包括监测本发明治疗效果的方法。
• USE OF GLP-2 IN COMBINATION WITH ANOTHER THERAPEUTIC AGENT IN BONE-RELATED AND NUTRITION-RELATED DISORDERS
  申请人：Osteometer Biotech AS

  公开号：EP1414486A2

  公开（公告）日：2004-05-06
• US4235887A
  申请人：——

  公开号：US4235887A

  公开（公告）日：1980-11-25