dihydrocubebin | 4621-68-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 二苄基丁烷木脂素
• 英文名称: dihydrocubebin
• 英文别名: 2,3-bis-benzo[1,3]dioxol-5-ylmethyl-butane-1,4-diol；2,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)butane-1,4-diol；2,3-Bis(1,3-benzodioxol-5-ylmethyl)butane-1,4-diol
• CAS: 4621-68-5；24562-96-7；24563-03-9；103619-39-2
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: JKCVMTYNARDGET-UHFFFAOYSA-N

物化性质

• 熔点：
  92 °C
• 沸点：
  586.8±50.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  sesamin 在 palladium 10% on activated carbon 甲酸 、 甲酸铵 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 4.0h， 以90%的产率得到dihydrocubebin
  参考文献：
  名称：

  [EN] REDUCTION OF C-0 BONDS BY CATALYTIC TRANSFER HYDROGENOLYSIS
  [FR] RÉDUCTION DE LIAISONS C-O PAR HYDROGÉNOLYSE PAR TRANSFERT CATALYTIQUE

  摘要：

  本发明涉及一种将底物中的C-O键还原为相应的C-H键的方法，该底物可以是苄基醇、烯丙基醇、酯类、醚类或位于氢氧基团β位或羰基α位的醚键。

  公开号：

  WO2012121659A1

文献信息

• REDUCTION OF C-0 BONDS BY CATALYTIC TRANSFER HYDROGENOLYSIS
  申请人：Kat2Biz AB

  公开号：EP2683677A1

  公开（公告）日：2014-01-15
• [EN] LIGNAN COMPOSITIONS<br/>[FR] COMPOSITIONS À BASE DE LIGNANES
  申请人：ALPINIA LAUDANUM INST OF PHYTOPHARMACEUTICAL SCIENCES AG

  公开号：WO2014086379A1

  公开（公告）日：2014-06-12

  The present invention provides pharmaceutical compositions comprising lignans, which are useful in the treatment or prevention of tumour and/or cancer diseases, in particular for the treatment or prevention of hormone-dependent tumour and/or cancer diseases, such as prostate cancer. Furthermore, the present invention relates to a process for obtaining a lignan composition from lignan-containing plant material, such as from Piper cubeba L., as well as to the use of the lignan composition obtainable by such process as a medicament.
• [EN] LIGNAN COMPOSITIONS<br/>[FR] COMPOSITIONS DE LIGNANE
  申请人：ALPINIA LAUDANUM INST OF PHYTOPHARMACEUTICAL SCIENCES AG

  公开号：WO2014086480A1

  公开（公告）日：2014-06-12

  The present invention provides pharmaceutical compositions comprising lignans, which are useful in the treatment or prevention of tumour and/or cancer diseases, in particular for the treatment or prevention of hormone-dependent tumour and/or cancer diseases, such as prostate cancer. Furthermore, the present invention relates to a process for obtaining a lignan composition from lignan-containing plant material, such as from Piper cubeba L., as well as to the use of the lignan composition obtainable by such process as a medicament.
• [EN] REDUCTION OF C-0 BONDS BY CATALYTIC TRANSFER HYDROGENOLYSIS<br/>[FR] RÉDUCTION DE LIAISONS C-O PAR HYDROGÉNOLYSE PAR TRANSFERT CATALYTIQUE
  申请人：SAMEC JOSEPH

  公开号：WO2012121659A1

  公开（公告）日：2012-09-13

  The present invention relates to a method of reducing a C-O bond to the corresponding C-H bond in a substrate which could be a benzylic alcohol, allylic alcohol, ester,or ether or an ether bond beta to a hydroxyl group or alpha to a carbonyl group.

  本发明涉及一种将底物中的C-O键还原为相应的C-H键的方法，该底物可以是苄基醇、烯丙基醇、酯类、醚类或位于氢氧基团β位或羰基α位的醚键。