(2R,3S)-1,4-二(4-羟基-3-甲氧基苯基)-2,3-二甲基丁烷-1-酮 | 154677-96-0

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 二苄基丁烷木脂素
• 中文名称: (2R,3S)-1,4-二(4-羟基-3-甲氧基苯基)-2,3-二甲基丁烷-1-酮
• 英文名称: cinnamophilin
• 英文别名: (2r,3s)-1,4-Bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutan-1-one
• CAS: 154677-96-0
• 化学式: C₂₀H₂₄O₅
• 分子量: 344.408
• InChiKey: FPJCOLPRFZWPHM-QWHCGFSZSA-N

物化性质

• 沸点：
  541.1±50.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R,3S)-1,4-二(4-羟基-3-甲氧基苯基)-2,3-二甲基丁烷-1-酮 在 吡啶 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 4-[(2S,3R)-4-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
  参考文献：
  名称：

  Lignans and an aromatic acid from Cinnamomum philippinense

  摘要：

  Investigation of the root of Cinnamomum philippinense resulted in the isolation of a new lignan, cinnamophilin, together with three known compounds, meso-dihydroguaiaretic acid, (+)-guaiacin and vallinic acid. Their structures were elucidated by spectral analysis. Cinnamophilin and its derivatives showed significant antiplatelet aggregation activity and vasorelaxing effect. Furthermore, it displayed antioxidative activity equivalent to alpha-tocopherol.

  DOI：

  10.1016/s0031-9422(00)89818-0

文献信息

• Lignans and an aromatic acid from Cinnamomum philippinense
  作者：Tian-Shung Wu、Yann-Lii Leu、Yu-Yi Chan、Sheu-Meei Yu、Che-Ming Teng、Jeng-De Su

  DOI：10.1016/s0031-9422(00)89818-0

  日期：1994.6

  Investigation of the root of Cinnamomum philippinense resulted in the isolation of a new lignan, cinnamophilin, together with three known compounds, meso-dihydroguaiaretic acid, (+)-guaiacin and vallinic acid. Their structures were elucidated by spectral analysis. Cinnamophilin and its derivatives showed significant antiplatelet aggregation activity and vasorelaxing effect. Furthermore, it displayed antioxidative activity equivalent to alpha-tocopherol.