acetic acid-(17β-hydroxy-17α-methyl-5α-androstanyl-(3β)-ester) | 64243-03-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: acetic acid-(17β-hydroxy-17α-methyl-5α-androstanyl-(3β)-ester)
• 英文别名: (10S)-17c-Hydroxy-3c-acetoxy-10r.13c.17t-trimethyl-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；Essigsaeure-(17β-hydroxy-17α-methyl-5α-androstanyl-(3β)-ester)；3β-Acetoxy-17α-methyl-5α-androstanol-(17β)
• CAS: 64243-03-4
• 化学式: C₂₂H₃₆O₃
• 分子量: 348.526
• InChiKey: FICAILCZWWKTGD-JHSHEYHPSA-N

物化性质

• 沸点：
  431.0±18.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  25.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  acetic acid-(17β-hydroxy-17α-methyl-5α-androstanyl-(3β)-ester) 在 三氧化硫吡啶 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 [(3S,5S,8R,9S,10S,13S,14S,17R)-17-hydroxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] acetate
  参考文献：
  名称：

  人类中17种α-甲基同化类固醇的17-表异构化：17种α-羟基-17β-甲基类固醇的代谢和合成。

  摘要：

  17个β-二醇（XIX）（也是VI，VII和XI的代谢物），17个α-甲基-5α-雄甾烷3β，17个β-二醇（XX），17个α-甲基-5β-雄烷醇-3 alpha，17 beta-diol（XXI）（也是V，VII和VIII的代谢物），17 alpha-methyl-5 beta-androstane-3 beta，17 beta-diol（XXII）和17 beta-hydroxy -7α，17α-二甲基-5β-雄烷-3-酮（XXIII）是通过17β-硫酸盐合成的，该硫酸盐在水中自发水解成几种脱水产物，再合成为17α-羟基-17β-甲基差向异构体。通过使17β-羟基-17α-甲基甾族化合物与三氧化硫吡啶配合物反应来制备17β-硫酸盐。在相应的17个α-甲基差向异构体之前，从毛细管SE-54或OV-1色谱柱的70-170个亚甲基单元中，将17种β-甲基差向异构体作为三甲基甲硅烷基衍生物从气

  DOI：

  10.1016/0039-128x(92)90023-3
• 作为产物：
  描述：

  acetic acid-(17β-hydroxy-17α-methyl-androsten-(5)-yl-(3β)-ester) 在 溶剂黄146 、 铂 作用下， 生成 acetic acid-(17β-hydroxy-17α-methyl-5α-androstanyl-(3β)-ester)
  参考文献：
  名称：

  GB454790

  摘要：

  公开号：

文献信息

• Metal salt oxidations of steroid olefins
  作者：G. Ortar、I. Torrini

  DOI：10.1016/0040-4020(77)80035-5

  日期：1977.1

  Oxidative rearrangements during the title reaction give 2,3 and 4 when lead(IV) acetate is used. The major products from thalIium(III) oxidation are the allylic ethers 5, 6 and 7. Oxymercuration-demercuration followed by acetylation gives 8 and 10 in addition to the ‘normal’ compound 9. The general rules previously developed for the metal salt oxidation of simple olefins depend on the nature of the

  标题反应过程中的重排的氧化得到2，3和4当使用四乙酸铅。从thalIium（III）氧化的主要产品是烯丙基醚5，6和7。除“正常”化合物9之外，加氧-脱汞后再进行乙酰化得到8和10。先前为简单烯烃的金属盐氧化开发的一般规则取决于底物的性质。
• Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking
  作者：Bradford H. Pillow、Clay Mash、Samuel Aloian、Valerie Hill

  DOI：10.1080/00221320209598673

  日期：2002.6

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.