1,3-dichloro-2,2,5,5-tetramethylimidazolidin-4-one | 128780-87-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3-dichloro-2,2,5,5-tetramethylimidazolidin-4-one
• CAS: 128780-87-0
• 化学式: C₇H₁₂Cl₂N₂O
• 分子量: 211.091
• InChiKey: VISGDCFUXPEFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-dichloro-2,2,5,5-tetramethylimidazolidin-4-one 在 sodium hydroxide 、 双氧水 作用下， 生成 2,2,5,5-四甲基咪唑烷-4-酮
  参考文献：
  名称：

  N,N'-dihaloimidazolidin-4-ones

  摘要：

  描述了在咪唑啉-4-酮环的2和5位置具有取代基的N-卤代衍生物。更具体地，描述了在环上选择了氢、烷基、烷氧基、羟基、苯基、取代苯基或螺环取代基的咪唑啉-4-酮的N-氯、N-溴、N,N'-二氯、N,N'-二溴和N,N'-溴氯衍生物。这些N-卤化合物是稳定的、不腐蚀的杀菌剂，对直射阳光具有抵抗力，并可用作消毒剂、消毒剂和藻类抑制剂。

  公开号：

  US05057612A1
• 作为产物：
  描述：

  2,2,5,5-四甲基咪唑烷-4-酮 生成 1,3-dichloro-2,2,5,5-tetramethylimidazolidin-4-one
  参考文献：
  名称：

  TSAO, TE-CHEN;WILLIAMS, DELBERT E.;WORLEY, CHRISTOPHER G.;WORLEY, S. DAVI+, BIOTECHNOL. PROGR., 7,(1991) N, C. 60-66

  摘要：

  DOI：

文献信息

• Ophthalmic devices containing heterocyclic compounds and methods for their production
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：EP1327893A1

  公开（公告）日：2003-07-16

  This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N-Cl and/or N-Br bond.

  本发明涉及眼科设备及其生产方法，其中眼科设备包含聚合物和至少一种杂环化合物，杂环化合物包含至少一个 N-Cl 和/或 N-Br 键。
• COMPOSITION FOR THE PREVENTION AND ELIMINATION OF ODORS
  申请人：OxiScience LLC

  公开号：EP3348144A2

  公开（公告）日：2018-07-18

  Articles can be provided with a high level of odor resistance by applying a dispersion of a halogenated heterocyclic N-halamine in an inert liquid carrier to the surface of the article and allowing the inert liquid carrier to penetrate into the article. However, it is important for the inert liquid carried not to react with halogen atoms in the halogenated heterocyclic N-halamine, and for the halogenated heterocyclic N-halamine to become deposited on the surface of the article after the inert liquid carrier penetrates into the article. This method can be used to provide a high level of odor resistance to a wide variety of substrates. It is of particular value for use in manufacturing garbage bags having a high level of odor resistance. It can also be used to deposit other functional particulates onto the surface of substrates that have porosity sufficient to take up the vehicle, including oxidants that may display antimicrobial and enzyme inhibitory efficacy, including, but not limited to N-halamines, and toxin interaction potentials both through oxidative degradation of toxic substances in air and water, and through adsorption interactions, such as fluoride uptake by metal oxide microparticles.

  将卤化杂环 N-卤胺在惰性液体载体中的分散液涂在物品表面，并让惰性液体载体渗入物品内部，可使物品具有较高的防臭性。然而，重要的是惰性液体载体不能与卤化杂环 N-卤胺中的卤素原子发生反应，并且在惰性液体载体渗入物品后，卤化杂环 N-卤胺要沉积在物品表面。这种方法可用于为各种基材提供高水平的抗异味能力。这种方法尤其适用于制造具有高抗臭性的垃圾袋。它还可用于将其他功能性微粒沉积到基材表面，这些基材具有足以吸收载体的孔隙率，其中包括可能具有抗菌和酶抑制功效的氧化剂，包括但不限于 N-卤胺，以及通过氧化降解空气和水中的有毒物质和通过吸附相互作用（如金属氧化物微粒对氟化物的吸收）产生的毒素相互作用潜力。
• Disinfecting and deodorizing compositions and methods with novel polymeric binding system
  申请人：Cao Zhengbing

  公开号：US10028482B2

  公开（公告）日：2018-07-24

  The present invention includes multifunctional compositions, methods and binding systems to provide disinfecting and deodorizing coatings for hard and soft surfaces, inorganic and organic solid surfaces and particulate media and other related substrates, including human and animal skin and skin lesions; to provide neutralizing functions for malodors generated by both human, animal and industrial fluids and solid wastes; and to provide neutralizing and degrading functions for nuisance and noxious chemicals. The present invention provides compositions and methods for producing disinfecting, oxidizing and enzyme-inhibiting fluids enabling preparation of durable, stable biocidal and deodorizing coatings and media which can be widely used for biological agent control, prevention and elimination of odors, and degradation of noxious agents susceptible to chemical oxidation, and which take forms that are inoffensive to users and offer high convenience.

  本发明包括多功能组合物、方法和结合系统，可为软硬表面、无机和有机固体表面和颗粒介质及其他相关基质（包括人类和动物皮肤和皮肤损伤）提供消毒和除臭涂层；为人类、动物和工业液体及固体废物产生的恶臭提供中和功能；以及为有害和有毒化学品提供中和和降解功能。本发明提供了生产消毒液、氧化液和酶抑制液的组合物和方法，从而能够制备持久、稳定的杀菌和除臭涂层和介质，这些涂层和介质可广泛用于生物制剂控制、防止和消除异味以及降解易受化学氧化影响的有害制剂，而且其形式不会引起使用者的反感，并提供了极大的便利。
• N-halamine containing fibrous compositions and uses thereof
  申请人：Auburn University

  公开号：US10178866B2

  公开（公告）日：2019-01-15

  The present disclosure provides fibrous composition comprising a soluble or a dispersible N-halamine, for example 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (i.e., compound I). Additionally, the disclosure provides methods for producing the fibrous compositions comprising a soluble or a dispersible N-halamine as well as methods for protecting a person from an infection using the fibrous compositions comprising a soluble or a dispersible N-halamine. The compositions and methods according to the present disclosure provide several advantages, such as stability, less time to provide sufficient antimicrobial inactivation, and are inexpensive and require lower amount of active concentrations to be effective.

  本公开提供了包含可溶性或分散性N-卤胺的纤维组合物，例如1-氯-2,2,5,5-四甲基-4-咪唑烷酮（即化合物I）。此外，本公开还提供了生产包含可溶性或可分散性 N-卤胺的纤维组合物的方法，以及使用包含可溶性或可分散性 N-卤胺的纤维组合物保护人免受感染的方法。根据本公开的组合物和方法具有若干优点，例如稳定性好，提供足够的抗微生物失活所需的时间较短，而且价格低廉，需要较低的活性浓度才能有效。
• Method of manufacturing particulate halogenated heterocyclic N-halamine compositions for the prevention and elimination of odors
  申请人：THE GLAD PRODUCTS COMPANY

  公开号：US10568982B2

  公开（公告）日：2020-02-25

  Articles can be provided with odor resistance by applying a dispersion of a halogenated heterocyclic N-halamine in an inert liquid carrier onto the surface of the article and allowing the inert liquid carrier to penetrate into it. The N-halamine accordingly becomes deposited on the surface of the article after the inert liquid carrier penetrates into the article. This method can be used to provide odor resistance to a variety of substrates, including garbage bags. It can also be used to deposit other functional particulates onto the surface of substrates having sufficient porosity to take up the vehicle. For instance, such functional particles can be oxidants that display antimicrobial and/or enzyme inhibitory efficacy or particles having toxin interaction potentials through oxidative degradation or adsorption of toxic substances in air and/or water, such as fluoride uptake by metal oxide microparticles.

  将惰性液体载体中的卤代杂环 N-卤胺分散液涂抹在物品表面，并让惰性液体载体渗入其中，可使物品具有防臭功能。在惰性液体载体渗入物品后，N-卤胺会相应地沉积在物品表面。这种方法可用于为包括垃圾袋在内的各种基材提供防臭功能。它还可用于将其他功能性微粒沉积到具有足够孔隙率以吸收载体的基材表面。例如，此类功能性微粒可以是具有抗菌和/或酶抑制功效的氧化剂，或通过氧化降解或吸附空气和/或水中的有毒物质（如金属氧化物微粒对氟化物的吸附）而具有毒素相互作用潜力的微粒。