Ethylpyruvat-2-methoxyphenylhydrazon | 33020-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethylpyruvat-2-methoxyphenylhydrazon
• 英文别名: Ethylpyruvat(o-methoxyphenyl)hydrazon；2-(2-methoxy-phenylhydrazono)-propionic acid ethyl ester；2-(2-Methoxy-phenylhydrazono)-propionsaeure-aethylester；ethyl pyruvate (o-methoxyphenyl)hydrazone；Ethyl 2-[2-(2-methoxyphenyl)hydrazin-1-ylidene]propanoate；ethyl 2-[(2-methoxyphenyl)hydrazinylidene]propanoate
• CAS: 33020-74-5
• 化学式: C₁₂H₁₆N₂O₃
• 分子量: 236.271
• InChiKey: ULTVEHQEMFNIMQ-UHFFFAOYSA-N

物化性质

• 沸点：
  333.0±44.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethylpyruvat-2-methoxyphenylhydrazon 在 磷酸 作用下， 生成 7-甲氧基吲哚-2-甲酸乙酯
  参考文献：
  名称：

  Indoline analogs of idazoxan: potent .alpha.2-antagonists and .alpha.1-agonists

  摘要：

  The synthesis and alpha-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 analogues; however, this alpha 2-antagonism is often accompanied by alpha 1-agonist activity. It was not possible to separate alpha 2-antagonist from alpha 1-agonist properties in this series. Compounds of most interest proved to be the N-ethyl 6, 5-chloro-N-methyl 18, and 5-chloro-N-ethyl 23 derivatives, all being potent alpha 2-antagonists and alpha 1-agonists. Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties.

  DOI：

  10.1021/jm00400a009
• 作为产物：
  描述：

  2-甲基乙酰乙酸乙酯 、 邻甲氧基苯胺 在 盐酸 、 氢氧化钾 、 sodium nitrite 作用下， 生成 Ethylpyruvat-2-methoxyphenylhydrazon
  参考文献：
  名称：

  Indoline analogs of idazoxan: potent .alpha.2-antagonists and .alpha.1-agonists

  摘要：

  The synthesis and alpha-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 analogues; however, this alpha 2-antagonism is often accompanied by alpha 1-agonist activity. It was not possible to separate alpha 2-antagonist from alpha 1-agonist properties in this series. Compounds of most interest proved to be the N-ethyl 6, 5-chloro-N-methyl 18, and 5-chloro-N-ethyl 23 derivatives, all being potent alpha 2-antagonists and alpha 1-agonists. Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties.

  DOI：

  10.1021/jm00400a009

文献信息

• 1'-Formyl-1'-halobenzeneazomethane compounds having herbicidal activity
  申请人：The Upjohn Company

  公开号：US04006132A1

  公开（公告）日：1977-02-01

  Compounds of the formula: ##STR1## WHEREIN R is alkyl of from 1 to 8 carbon atoms, inclusive; alkoxy of from 1 to 8 carbon atoms, inclusive; haloalkoxy of from 1 to 8 carbon atoms, inclusive; cycloalkyl of from 3 to 8 carbon atoms, inclusive; cycloalkoxy of from 3 to 8 carbon atoms, inclusive; or haloalkyl of from 1 to 8 carbon atoms, inclusive; R' is lower-alkyl of from 1 to 8 carbon atoms, inclusive, phenyl, cycloalkyl of from 3 to 8 carbon atoms, inclusive; or X; X is bromine, chlorine, or fluorine; m is an integer 0 through 5, inclusive, and Y is (independently when m is more than 1) halogen, lower-alkyl of from 1 to 4 carbon atoms, inclusive, lower-alkoxy of from 1 to 4 carbon atoms, inclusive, or halolower-alkyl of from 1 to 4 carbon atoms, inclusive; providing however, that m is 2 to 5 whenever R' is X, and that the sum of the carbon atoms in substituents (Y).sub.m is not more than 15.

  该化合物的分子式为：##STR1## 其中，R为1-8个碳原子的烷基、1-8个碳原子的烷氧基、1-8个碳原子的卤代烷氧基、3-8个碳原子的环烷基、3-8个碳原子的环烷氧基或1-8个碳原子的卤代烷基；R'为1-8个碳原子的较低烷基、苯基、3-8个碳原子的环烷基或X；X为溴、氯或氟；m为0-5的整数，Y为（当m大于1时）卤素、1-4个碳原子的较低烷基、1-4个碳原子的较低烷氧基或1-4个碳原子的卤代较低烷基。但是，当R'为X时，m为2-5，并且取代基（Y）的碳原子总数不超过15。