octahydro-quinoline | 72925-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: octahydro-quinoline
• 英文别名: octahydroquinoline；1,2,3,4,5,6,7,8-Octahydroquinoline
• CAS: 72925-27-0
• 化学式: C₉H₁₅N
• mdl: MFCD13176227
• 分子量: 137.225
• InChiKey: KBEKBFIHNWRZQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  octahydro-quinoline 、 乙酸酐 以70%的产率得到
  参考文献：
  名称：

  MAHOJAN J. R.; NUNES B. J.; ARAUJO H. C.; FERREIRA G. A. L., J. CHEM. RES. SYNOP., 1979, NO 9, 284, (M 3158-3173)

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-7-吗啉苯并[d]噻唑-2-胺 以79%的产率得到Octahydro-quinoline-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
  参考文献：
  名称：

  Benzothiazole derivatives with activity as adenosine receptor ligands

  摘要：

  本发明涉及替代苯并噻唑衍生物及其药用可接受的盐，用于治疗与腺苷受体相关的疾病。

  公开号：

  US20020045615A1

文献信息

• [EN] 3-SULFONYL-5-AMINOPYRIDINE-2,4-DIOL APJ AGONISTS<br/>[FR] AGONISTES D'APJ DE 3-SULFONYL-5-AMINOPYRIDINE -2,4-DIOL
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018071622A1

  公开（公告）日：2018-04-19

  The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

  本发明提供了一种化合物，其化学式为（I），其中所有变量均如规范中定义，并包括任何这种新化合物的组合物。这些化合物是APJ激动剂，可用作药物。
• Novel additives for imparting mar and scratch resistance and compositions comprising the same
  申请人：——

  公开号：US20040116585A1

  公开（公告）日：2004-06-17

  Additives comprising dispersed silica nanoparticles are disclosed. The silica nanoparticles are dispersed in an aminoplast, such as a modified aminoplast formed from the reaction between an aminoplast, a modifying component, and optionally a siloxane. The resulting additives can be added to coating compositions to provide improved mar and/or scratch resistance.

  本发明涉及含有分散的二氧化硅纳米颗粒的添加剂。这些二氧化硅纳米颗粒被分散在氨基塑料中，例如由氨基塑料、改性组分和可选的硅氧烷反应形成的改性氨基塑料中。由此产生的添加剂可添加到涂料组合物中，以提供改善的耐磨和/或耐刮擦性能。
• Novel additives for imparting Mar and scratch resistance and compositions comprising the same
  申请人：Ambrose R. Ronald

  公开号：US20060078748A1

  公开（公告）日：2006-04-13

  Additives comprising dispersed silica nanoparticles are disclosed. The silica nanoparticles are dispersed in an aminoplast, such as a modified aminoplast formed from the reaction between an aminoplast, a modifying component, and optionally a siloxane. The resulting additives can be added to coating compositions to provide improved mar and/or scratch resistance.

  公开了包含分散的二氧化硅纳米颗粒的添加剂。二氧化硅纳米颗粒分散在胺基塑料中，例如由胺基塑料、修饰组分和可选的硅氧烷反应形成的改性胺基塑料。所得到的添加剂可添加到涂料组合物中，以提供更好的抗刮擦性能。
• Modified aminoplast crosslinkers and powder coating compositions containing such crosslinkers
  申请人：——

  公开号：US20020037973A1

  公开（公告）日：2002-03-28

  A crosslinking agent is provided, prepared by reacting (A) an aminoplast resin; (B) a reactive urethane group-containing adduct of a polyfunctional polymer and monoisocyanate, and (C) at least one other compound having active hydrogen groups reactive with aminoplast resin (A). Compound (C) is selected from: (i) compounds having the structure (I): 1 wherein X is aromatic; R 1 , R 2 , and R 3 each independently represents H, (cyclo)alkyl having from 1 to 12 carbon atoms, aryl, alkaryl, aralkyl, or an active hydrogen-containing group, (ii) compounds having the structure (II) or (III): 2 where R′ and R″ each independently represents an aromatic group or an alkyl group having 1 to 12 carbon atoms; and (iii) compounds different from (i) and (ii), having a melting point of at least 80° C. Further provided are methods for preparing the crosslinking agent, curable compositions containing the crosslinking agent, and coated substrates.

  本发明提供了一种交联剂，其制备方法是：(A)氨基树脂；(B)多官能团聚合物和单异氰酸酯的含活性聚氨酯基的加合物；(C)至少一种具有与氨基树脂(A)反应的活性氢基的其他化合物。化合物（C）选自 (i) 具有结构 (I) 的化合物： 1 其中 X 为芳香族； R 1 , R 2 和 R 3 各自独立地代表 H、具有 1 至 12 个碳原子的（环）烷基、芳基、烷芳基、芳烷基或活性含氢基团、 (ii) 具有结构 (II) 或 (III) 的化合物： 2 其中 R′和 R″各自独立地代表芳香基团或具有 1 至 12 个碳原子的烷基；以及 (iii) 不同于(i)和(ii)的化合物，其熔点至少为 80℃。 进一步提供了制备交联剂的方法、含有交联剂的可固化组合物和涂覆基材。
• Sulfonamide modified aminoplast crosslinkers and powder coating compositions containing such crosslinkers
  申请人：——

  公开号：US20030100686A1

  公开（公告）日：2003-05-29

  A crosslinking agent that is an ungelled reaction product of (a) an aminoplast resin and (b) a compound having active hydrogen groups reactive with the aminoplast resin such that the crosslinking agent is essentially free of functional groups reactive with an aminoplast resin and has a glass transition temperature of at least 10° C. is disclosed. Compound (b) is, more specifically, a monofunctional sulfonamide having only one active hydrogen. Methods for preparing crosslinking agents are also disclosed. Further provided is a curable powder coating composition including a polymer having a glass transition temperature of at least 30° C. containing reactive functional groups and the present crosslinking agent; a multilayer composite coating compositions and substrates coated therewith are also disclosed. Methods for modifying aminoplasts are also disclosed.

  本发明公开了一种交联剂，它是(a)氨基树脂和(b)具有与氨基树脂反应的活性氢基的化合物的未胶化反应产物，这样的交联剂基本上不含与氨基树脂反应的官能团，且玻璃化转变温度至少为 10 摄氏度。更具体地说，化合物 (b) 是一种只有一个活性氢的单官能度磺酰胺。还公开了制备交联剂的方法。进一步提供了一种可固化的粉末涂料组合物，包括一种玻璃化转变温度至少为30℃的含有活性官能团的聚合物和本发明的交联剂；还公开了一种多层复合涂料组合物和涂覆其的基材。此外，还公开了改性氨基细胞的方法。