3-(4-Methoxyanilino)-1-(4-methylphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-Methoxyanilino)-1-(4-methylphenyl)prop-2-en-1-one
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: PISIXTVXKZVTBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-Methoxyanilino)-1-(4-methylphenyl)prop-2-en-1-one 在 copper dichloride 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以54%的产率得到2-chloro-3-((4-methoxyphenyl)amino)-1-(p-tolyl)prop-2-en-1-one
  参考文献：
  名称：

  直接铜（II）介导的N-芳基烯胺酮的区域选择性α-卤化

  摘要：

  开发了温和的铜（II）介导的N-芳基烯胺酮的α卤代。使用CuX 2在40°C的乙醇中以中等至良好的产率获得α-卤化的N-芳基烯酮。

  DOI：

  10.1016/j.tetlet.2016.09.076
• 作为产物：
  描述：

  3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one 、 甲氧苯胺 在 iron(III) chloride 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 3-(4-Methoxyanilino)-1-(4-methylphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Base-Promoted Synthesis of N-Substituted 1,2,3-Triazoles via Enaminone–Azide Cycloaddition Involving Regitz Diazo Transfer

  摘要：

  The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various N-substituted 1,2,3-triazoles by employing t-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azide, the reactions proceed efficiently at room temperature with good substrate tolerance.

  DOI：

  10.1021/acs.orglett.6b02975

文献信息

• Facile, regioselective oxidative selenocyanation of <i>N</i>-aryl enaminones under transition-metal-free conditions
  作者：Ganesh Shivayogappa Sorabad、Mahagundappa Rachappa Maddani

  DOI：10.1039/c9nj05845a

  日期：——

  The present selenocyanation is applied for the synthesis of selenocyanated chromones, indoles and anilines in good to excellent yields.

  目前的硒氰化反应用于合成硒氰基的咖啡因、吲哚和苯胺，产率在良好到优异之间。
• Base-Promoted Synthesis of <i>N</i>-Substituted 1,2,3-Triazoles via Enaminone–Azide Cycloaddition Involving Regitz Diazo Transfer
  作者：Jie-Ping Wan、Shuo Cao、Yunyun Liu

  DOI：10.1021/acs.orglett.6b02975

  日期：2016.12.2

  The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various N-substituted 1,2,3-triazoles by employing t-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azide, the reactions proceed efficiently at room temperature with good substrate tolerance.
• Direct copper(II)-mediated regioselective α-halogenation of N-aryl enaminones
  作者：Hui Xu、Pan Zhou、Rong Hang、Jie Zhou、Ling-Ling Lu、Yuehai Shen、Fu-Chao Yu

  DOI：10.1016/j.tetlet.2016.09.076

  日期：2016.11

  A mild copper(II)-mediated α-halogenation of N-aryl enaminones was developed. α-Halogenated N-aryl enaminones were obtained in moderate to good yields using CuX2 in EtOH at 40 °C.

  开发了温和的铜（II）介导的N-芳基烯胺酮的α卤代。使用CuX 2在40°C的乙醇中以中等至良好的产率获得α-卤化的N-芳基烯酮。