Intramolecular Radical Amidooxygenation of Alkenes for the Construction of Pyrrolidinones
作者:Anirban Maity、Armido Studer
DOI:10.1021/acs.orglett.4c01607
日期:2024.6.7
An intramolecular 1,2-amidooxygenation of unactivated alkenes for the construction of the pyrrolidinone scaffold containing a masked 5-hydroxymethyl functionality is reported. γ,δ-Unsaturated N-aryloxyamides react with sodium 2,2,6,6-tetramethylpiperidin-1-olate (TEMPONa) to afford alkoxyaminated pyrrolidinones. The cascade proceeds through reductive amidyl radical generation with TEMPONa, 5-exo cyclization