3,4'-bis(methoxycarbonylphenyl)methanone | 26163-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4'-bis(methoxycarbonylphenyl)methanone
• 英文别名: m,p'-Dicarbomethoxybenzophenon；Methyl 3-(4-methoxycarbonylbenzoyl)benzoate
• CAS: 26163-23-5
• 化学式: C₁₇H₁₄O₅
• 分子量: 298.295
• InChiKey: FWKBCAQSKHWDSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,4'-bis(methoxycarbonylphenyl)methanone 在 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 methyl 3-[(Z)-N-hydroxy-C-(4-methoxycarbonylphenyl)carbonimidoyl]benzoate 、
  参考文献：
  名称：

  A Novel Class of Potent Nonglycosidic and Nonpeptidic Pan-Selectin Inhibitors

  摘要：

  An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy Lewis(x) is a ligand for E-, P-, and L-selectin and therefore serves as a lead structure for the development of analogues. A combination of synthesis and structure-based design allowed rapid optimization. The current lead 2a was evaluated in our E-selectin cell flow chamber assay where it proved to inhibit rolling and adhesion with an IC50 of 28 +/- 7 mu M. The assays used are predictive for the in vivo efficacy of test compounds as shown for 2a in a proteose peptone induced peritonitis model of acute inflammation in mice.

  DOI：

  10.1021/jm060468y
• 作为产物：
  描述：

  3-碘苯甲酸甲酯 在 异丙基氯化镁 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.67h， 生成 3,4'-bis(methoxycarbonylphenyl)methanone
  参考文献：
  名称：

  A Novel Class of Potent Nonglycosidic and Nonpeptidic Pan-Selectin Inhibitors

  摘要：

  An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy Lewis(x) is a ligand for E-, P-, and L-selectin and therefore serves as a lead structure for the development of analogues. A combination of synthesis and structure-based design allowed rapid optimization. The current lead 2a was evaluated in our E-selectin cell flow chamber assay where it proved to inhibit rolling and adhesion with an IC50 of 28 +/- 7 mu M. The assays used are predictive for the in vivo efficacy of test compounds as shown for 2a in a proteose peptone induced peritonitis model of acute inflammation in mice.

  DOI：

  10.1021/jm060468y

文献信息

• POLYMERIZATION OF ALIPHATIC-AROMATIC COPOLYETHERESTERS
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2358783A1

  公开（公告）日：2011-08-24
• POLYMERIZATION WITH ENHANCED GLYCOL ETHER FORMATION
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2365992A1

  公开（公告）日：2011-09-21
• POLYMERIZATION WITH ENHANCED GLYCOL ETHER FORMULATION
  申请人：Hasty Noel M.

  公开号：US20110206883A1

  公开（公告）日：2011-08-25

  The polymerization processes described herein provide methods for dehydrating diols such that dimers of the diols are formed and incorporated into polyesters during polycondensation. Control over this phenomenon provides unique polymer compositions with a range of thermo-mechanical properties, crystallinity, bio-content and biodegradability. Generation of a wide range of properties allows development of polymers that can be used for a wide range of applications.
• [EN] POLYMERIZATION WITH ENHANCED GLYCOL ETHER FORMATION<br/>[FR] POLYMÉRISATION AVEC FORMATION AMÉLIORÉE DE GLYCOL ÉTHER
  申请人：DU PONT

  公开号：WO2010071771A1

  公开（公告）日：2010-06-24

  The polymerization processes described herein provide methods for dehydrating diols such that dimers of the diols are formed and incorporated into polyesters during polycondensation. Control over this phenomenon provides unique polymer compositions with a range of thermo-mechanical properties, crystallinity, bio-content and biodegradability. Generation of a wide range of properties allows development of polymers that can be used for a wide range of applications.
• [EN] POLYMERIZATION OF ALIPHATIC-AROMATIC COPOLYETHERESTERS<br/>[FR] POLYMÉRISATION DE COPOLYÉTHERESTERS ALIPHATIQUES-AROMATIQUES
  申请人：DU PONT

  公开号：WO2010075030A1

  公开（公告）日：2010-07-01

  The polymerization processes described herein provide methods for controlling the dehydration of glycols such that dimers are formed as glycol ethers and incorporated into aliphatic-aromatic copolyetheresters during polycondensation. Control over this phenomenon provides unique polymer compositions with a range of thermo-mechanical properties, crystallinity, bio-content and biodegradability.