2-(3-chloromethyl-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester | 773071-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chloromethyl-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester
• 英文别名: 2-(3-Chloromethyl-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester；ethyl 2-[[3-(chloromethyl)benzoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• CAS: 773071-11-7
• 化学式: C₁₉H₂₀ClNO₃S
• 分子量: 377.892
• InChiKey: SNXLAMSXEQBFCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-chloromethyl-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 、 N,N-二乙基乙二胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以100%的产率得到2-{3-[(2-diethylamino-ethylamino)-methyl]-benzoylamino}-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  EP1614676

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯 、 3-(氯甲基)苯甲酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以100%的产率得到2-(3-chloromethyl-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  EP1614676

  摘要：

  公开号：

文献信息

• Compound inhibiting in vivo phosphorous transport and medicine containing the same
  申请人：Eto Nobuaki

  公开号：US20060217426A1

  公开（公告）日：2006-09-28

  An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and represents a single bond or a double bond, R 5 represents optionally substituted aryl or the like, Z represents —N═CHR 6 R 7 or the like, R 6 and R 7 represent H, optionally substituted alkyl, optionally substituted aryl or the like, R 101 and R 102 together form ═O, and R 103 and R 104 represent H, or R 101 and R 104 together from a bond, and R 102 and R 103 together form a bond.

  本发明的目标是提供能够有效抑制血清中磷浓度的化合物，以有效预防或治疗由血清中磷酸盐浓度增加引起的疾病。本发明的化合物是由式（I）所表示的化合物及其药学上可接受的盐和溶剂化物：其中，A表示可选取的取代的五元至九元不饱和碳环状基团或五元至九元不饱和杂环状基团，表示单键或双键，R5表示可选取的取代芳基或类似物，Z表示—N═CHR6R7或类似物，R6和R7表示H、可选取的取代烷基、可选取的取代芳基或类似物，R101和R102共同形成═O，R103和R104表示H，或R101和R104共同形成键，R102和R103共同形成键。
• COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME
  申请人：Eto Nobuaki

  公开号：US20120115851A1

  公开（公告）日：2012-05-10

  An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and represents a single bond or a double bond, R 5 represents optionally substituted aryl or the like, Z represents —N═CHR 6 R 7 or the like, R 6 and R 7 represent H, optionally substituted alkyl, optionally substituted aryl or the like, R 101 and R 102 together form ═O, and R 103 and R 104 represent H, or R 101 and R 104 together from a bond, and R 102 and R 103 together form a bond.

  本发明的目标是提供能够有效抑制血清中磷浓度的化合物，以有效预防或治疗由血清中磷酸盐浓度增加引起的疾病。本发明的化合物是由式（I）表示的化合物及其药学上可接受的盐和溶剂化物：其中，A代表可选取代的五至九元不饱和碳环基或五至九元不饱和杂环基，表示单键或双键，R5代表可选取代的芳基或类似物，Z代表—N═CHR6R7或类似物，R6和R7代表H、可选取代的烷基、可选取代的芳基或类似物，R101和R102共同形成═O，R103和R104代表H，或R101和R104共同形成键，R102和R103共同形成键。
• AMINOALKYL-SUBSTITUTED N-THIENYLBENZAMIDE DERIVATIVE
  申请人：ASTELLAS PHARMA INC.

  公开号：US20150031727A1

  公开（公告）日：2015-01-29

  [Problem] To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. [Means for Solution] The present inventors conducted their studies on a compound that has an NPT-IIb inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. As a result, they created an aminoalkyl-substituted N-thienylbenzamide derivative which has NPT-IIb inhibitory action, thereby completing the present invention. The aminoalkyl-substituted N-thienylbenzamide derivative of the present invention has an NPT-IIb inhibitory action and can be used as an agent for preventing and/or treating hyperphosphatemia.

  【问题】提供一种具有肠道磷酸转运体（NPT-IIb）抑制作用并且可用作治疗和/或预防高磷血症药物的活性成分的化合物。【解决方案】本发明人对一种具有NPT-IIb抑制作用并且可用作治疗和/或预防高磷血症药物的活性成分的化合物进行了研究。结果，他们创造了一种具有NPT-IIb抑制作用的氨基烷基取代的N-噻吩基苯酰胺衍生物，从而完成了本发明。本发明的氨基烷基取代的N-噻吩基苯酰胺衍生物具有NPT-IIb抑制作用，并可用作预防和/或治疗高磷血症的药物。
• AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP2772490B1

  公开（公告）日：2016-04-06
• US8134015B2
  申请人：——

  公开号：US8134015B2

  公开（公告）日：2012-03-13