O-甲基-D-苏氨酸 | 537697-28-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: O-甲基-D-苏氨酸
• 英文名称: (2R,3S)-2-amino-3-methoxybutanoic acid
• 英文别名: DL-O-Methyl-threonin；L-(2R:3S)-O-Methylthreonin；O-methyl-D_S-threonine；O-Methyl-D_S-threonin；O-Methyl-D&s&-threonin; (2R,3S)-2-Amino-3-methoxy-buttersaeure；(2R:3S)-2-Amino-3-methoxy-buttersaeure；O-methyl-d-threonine
• CAS: 537697-28-2
• 化学式: C₅H₁₁NO₃
• 分子量: 133.147
• InChiKey: FYCWLJLGIAUCCL-IUYQGCFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O-甲基-D-苏氨酸 在 sodium hydroxide 作用下， 生成 N,O-dimethyl-N-(toluene-4-sulfonyl)-D_S-threonine
  参考文献：
  名称：

  Izumiya, Nippon Kagaku Zasshi, 1950, vol. 71, p. 500

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl (2R,3S)-2-(tert-butoxycarbonylamino)-3-methoxybutanoate 在 盐酸 作用下， 以 水 为溶剂， 反应 16.0h， 生成 O-甲基-D-苏氨酸
  参考文献：
  名称：

  Minutissamides E–L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp.

  摘要：

  The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolation of a series of cyclic lipodecapeptides, named minutissamides E-L (1-8). The planar structures were determined by analysis of HRESIMS, tandem MS, and 1D and 2D NMR data, and the stereo-configurations were assigned by LC-MS analysis of the Marfey's derivatives after acid hydrolysis. Minutissamides E-L (1-8) exhibited antiproliferative activity against MDA-MB-435 cells with IC50 values ranging between 1 and 10 mu M. The structures of minutissamides E-L (1-8) were closely related with those of the previously reported lipopeptides, puwainaphycins A-E and minutissamides A-D, characterized by the presence of a lipophilic beta-amino acid and three non-standard amino acids NMeAsn, OMeThr and Dhb (alpha,beta-dehydro-alpha-aminobutyric acid). The strain UIC 10035 was designated as cf. Anabaena sp. on the basis of morphological and 16S rRNA gene sequence analyses. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.08.017

文献信息

• [EN] IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17<br/>[FR] IMIDAZOPYRIDAZINES EN TANT QUE MODULATEURS DE L'IL-17
  申请人：JANSSEN BIOTECH INC

  公开号：WO2021222404A1

  公开（公告）日：2021-11-04

  The present application discloses compounds having the following formula: (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

  本申请公开了具有以下公式(I)的化合物，或其药用可接受的盐，其中R1、R2、R3、R4和R5在说明书中定义，以及制造和使用所公开化合物的方法，用于治疗或改善IL-17介导的综合征、紊乱和/或疾病。
• Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1
  作者：Cynthia A Fink、Michael Moskal、Fariborz Firooznia、Denton Hoyer、David Symonsbergen、Dongchu Wei、Ying Qiao、Paula Savage、Michael E Beil、Angelo J Trapani、Arco Y Jeng

  DOI：10.1016/s0960-894x(00)00403-0

  日期：2000.9

  Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084, that had potent endothelin converting enzyme-1 (ECE-1) in vitro inhibitory activity (IC50 = 77 nM) was identified. Herein we report the synthesis and optimization of ECE-1 inhibitory activity of additional analogues from this lead. Compound 3c, the thioacetate methyl ester derivative of compound 4c, was found to be a long acting inhibitor of ECE-1 activity in rats after oral administration. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei
  作者：Carmen Festa、Simona De Marino、Valentina Sepe、Maria Chiara Monti、Paolo Luciano、Maria Valeria D'Auria、Cecile Débitus、Mariarosaria Bucci、Valentina Vellecco、Angela Zampella

  DOI：10.1016/j.tet.2009.10.026

  日期：2009.12

  Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are reported. (C) 2009 Elsevier Ltd. All rights reserved.
• West; Carter, Journal of Biological Chemistry, 1937, vol. 119, p. 104,105
  作者：West、Carter

  DOI：——

  日期：——
• Izumiya, 1952, vol. 3, p. 1,3
  作者：Izumiya

  DOI：——

  日期：——